MAP3K12 抗体
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北京 101111
Quick Overview for MAP3K12 抗体 (ABIN3031847)
抗原
See all MAP3K12 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Antigen affinity purified
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免疫原
- This DLK antibody was produced from rabbits immunized with a recombinant protein of human DLK.
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亚型
- Ig Fraction
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应用备注
- Titration of the DLK antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the DLK antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- MAP3K12 (Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12))
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别名
- DLK
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背景
- This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes, it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance, this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass.
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UniProt
- P80370
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途径
- MAPK Pathway
抗原
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