电话:
400-7060-959
传真:
+86 10 56315212-8813
电子邮件:
orders@antibodies-online.cn

AXL 抗体 (AA 838-872)

AXL 适用: 人, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3030090
发货至: 中国
  • 抗原 See all AXL 抗体
    AXL (AXL Receptor tyrosine Kinase (AXL))
    抗原表位
    • 20
    • 20
    • 20
    • 16
    • 15
    • 12
    • 11
    • 9
    • 8
    • 8
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 838-872
    适用
    • 136
    • 62
    • 54
    • 6
    • 5
    • 5
    • 5
    • 2
    • 1
    • 1
    人, 大鼠
    宿主
    • 123
    • 19
    • 3
    • 1
    克隆类型
    • 123
    • 23
    多克隆
    标记
    • 59
    • 12
    • 11
    • 10
    • 8
    • 8
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This AXL antibody is un-conjugated
    应用范围
    • 117
    • 69
    • 38
    • 26
    • 26
    • 21
    • 15
    • 9
    • 6
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    纯化方法
    Antigen affinity purified
    免疫原
    This AXL antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 838-872 amino acids from the C-terminal region of human AXL.
    亚型
    Ig Fraction
    Top Product
    Discover our top product AXL Primary Antibody
  • 应用备注
    Titration of the AXL antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Aliquot the AXL antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • 抗原
    AXL (AXL Receptor tyrosine Kinase (AXL))
    别名
    AXL (AXL 产品)
    别名
    JTK11 antibody, UFO antibody, AI323647 antibody, Ark antibody, Tyro7 antibody, Ufo antibody, AXL receptor tyrosine kinase antibody, Axl receptor tyrosine kinase antibody, AXL antibody, Axl antibody
    背景
    Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3, but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor. [UniProt]
    UniProt
    P30530
    途径
    RTK signaling, Cellular Response to Molecule of Bacterial Origin
You are here:
客服