AXL 抗体 (AA 838-872)
Quick Overview for AXL 抗体 (AA 838-872) (ABIN3030090)
抗原
See all AXL 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 838-872
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纯化方法
- Antigen affinity purified
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免疫原
- This AXL antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 838-872 amino acids from the C-terminal region of human AXL.
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亚型
- Ig Fraction
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anti-AXL Receptor tyrosine Kinase (AXL) (AA 30-140) antibody
AXL 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 6C8 unconjugated
anti-AXL Receptor tyrosine Kinase (AXL) antibodyAXL 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-AXL Receptor tyrosine Kinase (AXL) (AA 13-44) antibodyAXL 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-AXL Receptor tyrosine Kinase (AXL) (AA 151-250) antibodyAXL 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-AXL Receptor tyrosine Kinase (AXL) (AA 312-447) antibodyAXL 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-AXL Receptor tyrosine Kinase (AXL) (AA 21-202) antibodyAXL 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-AXL Receptor tyrosine Kinase (AXL) (AA 1-894) antibodyAXL 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-AXL Receptor tyrosine Kinase (AXL) antibodyAXL 适用: 人 ELISA, ICC 宿主: 小鼠 Monoclonal 7E10 unconjugated
anti-AXL Receptor tyrosine Kinase (AXL) (C-Term) antibodyKO Validated AXL 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-AXL Receptor tyrosine Kinase (AXL) (AA 787-885) antibodyAXL 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2C10 unconjugated
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应用备注
- Titration of the AXL antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the AXL antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- AXL (AXL Receptor tyrosine Kinase (AXL))
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别名
- AXL
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背景
- Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3, but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor. [UniProt]
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UniProt
- P30530
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途径
- RTK signaling, Cellular Response to Molecule of Bacterial Origin
抗原
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