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KCNT1 抗体 (AA 1168-1237)

KCNT1 适用: 大鼠, 小鼠 WB, IF, IP, IHC (fro) 宿主: 小鼠 Monoclonal S3-26 unconjugated
产品编号 ABIN492453
发货至: 中国
  • 抗原 See all KCNT1 抗体
    KCNT1 (Potassium Channel, Subfamily T, Member 1 (KCNT1))
    抗原表位
    • 15
    • 11
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1168-1237
    适用
    • 29
    • 18
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    大鼠, 小鼠
    宿主
    • 29
    • 12
    小鼠
    克隆类型
    • 29
    • 12
    单克隆
    标记
    • 13
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This KCNT1 antibody is un-conjugated
    应用范围
    • 33
    • 16
    • 13
    • 13
    • 11
    • 11
    • 11
    • 10
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))
    特异性
    Detects ~140 kDa protein.
    交叉反应 (详细)
    Species reactivity (expected):Human (weak), Mouse.
    Species reactivity (tested):Rat.
    产品特性
    Synonyms: KIAA1422, KCa4.1, Potassium channel subfamily T member 1
    纯化方法
    Protein G Chromatography
    免疫原
    Fusion protein amino acids 1168-1237 of Rat Slo2. 2 (Slack, NP_068625)
    克隆位点
    S3-26
    亚型
    IgG1
    Top Product
    Discover our top product KCNT1 Primary Antibody
  • 应用备注
    Western blot: 1 μg/mL (If results are poor use lysate without boiling, heat at 37 °C for 15 minutes).1 μg/mL was sufficient for detection of Slo2.2 in 10 μg of rat brain lysate by colorimetricimmunoblot analysis using Goat anti-mouse IgG: HRP as the secondary antibody. Immunoprecipitation: 1.0-10 μg/mLImmunofluorescence: 1.0-10 μg/mLImmunocytochemistry: 0.1-1.0 μg/mLImmunohistochemistry: 0.1-1.0 μg/mL
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS, pH 7.4 containing 50 % Glycerol as stabilizer and 0.09 % Sodium Azide as preservative
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    有效期
    12 months
  • 抗原
    KCNT1 (Potassium Channel, Subfamily T, Member 1 (KCNT1))
    别名
    KCNT1 (KCNT1 产品)
    别名
    EIEE14 antibody, ENFL5 antibody, KCa4.1 antibody, SLACK antibody, bA100C15.2 antibody, Slack antibody, rSlo2 antibody, C030030G16Rik antibody, mKIAA1422 antibody, slo2 antibody, slack antibody, Slo2.2 antibody, MGC146594 antibody, potassium sodium-activated channel subfamily T member 1 antibody, potassium channel subfamily T member 1 antibody, potassium channel, subfamily T, member 1 antibody, potassium channel, sodium activated subfamily T, member 1 antibody, KCNT1 antibody, LOC100436526 antibody, Kcnt1 antibody, kcnt1 antibody
    背景
    Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Slo2.2 is a novel member of the mammalian Slo potassium channel gene family. Slo2 channels may contribute to the resting potentials of cells that control their basal level of excitability (3). They also have sensors that couple channel activity to the intracellular concentrations of Na+ and Cl-(4).Synonyms: KCa4.1, KIAA1422, Potassium channel subfamily T member 1
    基因ID
    60444
    UniProt
    Q9Z258
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