Raptor 抗体
Quick Overview for Raptor 抗体 (ABIN4913788)
抗原
See all Raptor (RPTOR) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein G.
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免疫原
- This RPTOR antibody is generated from a mouse immunized with recombinant protein.
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亚型
- IgG1
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anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) antibody
RPTOR 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) (AA 874-1009) antibodyRPTOR 适用: 人 ELISA 宿主: 小鼠 Monoclonal 6G9C4 unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) (AA 13-128) antibodyRPTOR 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) (C-Term) antibodyRPTOR 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) antibodyRPTOR 适用: 人 ELISA, IHC 宿主: 兔 Monoclonal 1B10 unconjugated Recombinant Antibody
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) (AA 1005-1329) antibodyRPTOR 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 小鼠 Monoclonal 1411CT316-2-151-34 unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) (AA 101-150) antibodyRPTOR 适用: 人, 小鼠 WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) (AA 1-379) antibodyRPTOR 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) (AA 1-379) antibodyRPTOR 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) (pSer792) antibodyRPTOR 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- Raptor (RPTOR) (Regulatory Associated Protein of mTOR, Complex 1 (RPTOR))
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别名
- RPTOR
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背景
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Synonyms: KOG1, Mip1, Regulatory-associated protein of mTOR, Raptor, p150 target of rapamycin (TOR)-scaffold protein, RPTOR, KIAA1303
Background: Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals, functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis.
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基因ID
- 57521
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UniProt
- Q8N122
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途径
- PI3K-Akt Signaling, RTK signaling, AMPK Signaling, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development, Autophagy, BCR Signaling, Warburg Effect
抗原
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