ISG15 抗体
Quick Overview for ISG15 抗体 (ABIN4911217)
抗原
See all ISG15 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人
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纯化方法
- Purified by Protein G.
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免疫原
- This ISG15 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 1-165 amino acids from the N-terminal region of human ISG15.
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亚型
- IgG1
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anti-ISG15 Ubiquitin-Like Modifier (ISG15) (AA 1-165) antibody
ISG15 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-ISG15 Ubiquitin-Like Modifier (ISG15) (AA 1-165) antibodyISG15 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-ISG15 Ubiquitin-Like Modifier (ISG15) (Middle Region) antibodyISG15 适用: 人, 兔, Cow, 犬, 马, Pig, 绵羊, 山羊 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-ISG15 Ubiquitin-Like Modifier (ISG15) (AA 31-61) antibodyISG15 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-ISG15 Ubiquitin-Like Modifier (ISG15) antibodyISG15 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-ISG15 Ubiquitin-Like Modifier (ISG15) (AA 31-61), (N-Term) antibodyISG15 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB02791 unconjugated
anti-ISG15 Ubiquitin-Like Modifier (ISG15) (AA 39-68), (N-Term) antibodyISG15 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-ISG15 Ubiquitin-Like Modifier (ISG15) antibodyISG15 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-ISG15 Ubiquitin-Like Modifier (ISG15) (AA 80-129) antibodyISG15 适用: 人, 兔, Cow, 犬, 马, Pig, 绵羊 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-ISG15 Ubiquitin-Like Modifier (ISG15) (C-Term) antibodyISG15 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IF() -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- ISG15 (ISG15 Ubiquitin-Like Modifier (ISG15))
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别名
- ISG15
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背景
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Synonyms: G1P2, IP17, UCRP, IFI15, IMD38, hUCRP, Ubiquitin-like protein ISG15, Interferon-induced 15 kDa protein, Interferon-induced 17 kDa protein, Ubiquitin cross-reactive protein, ISG15
Background: Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Its target proteins include IFIT1, MX1/MxA, PPM1B, UBE2L6, UBA7, CHMP5, CHMP2A, CHMP4B and CHMP6. Can also isgylate: EIF2AK2/PKR which results in its activation, DDX58/RIG-I which inhibits its function in antiviral signaling response, EIF4E2 which enhances its cap structure-binding activity and translation-inhibition activity, UBE2N and UBE2E1 which negatively regulates their activity, IRF3 which inhibits its ubiquitination and degradation and FLNB which prevents its ability to interact with the upstream activators of the JNK cascade therby inhibiting IFNA-induced JNK signaling. Exhibits antiviral activity towards both DNA and RNA viruses, including influenza A, HIV-1 and Ebola virus. Restricts HIV-1 and ebola virus via disruption of viral budding. Inhibits the ubiquitination of HIV-1 Gag and host TSG101 and disrupts their interaction, thereby preventing assembly and release of virions from infected cells. Inhibits Ebola virus budding mediated by the VP40 protein by disrupting ubiquitin ligase activity of NEDD4 and its ability to ubiquitinate VP40. ISGylates influenza A virus NS1 protein which causes a loss of function of the protein and the inhibition of virus replication. The secreted form of ISG15 can: induce natural killer cell proliferation, act as a chemotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity.
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基因ID
- 9636
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UniProt
- P05161
抗原
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