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- 抗原 See all PTGS2 抗体
- PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PTGS2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 产品特性
- Cyclooxygenase1 (Cox1) and cyclooxygenase2 (Cox2), family members with 60 % homology in humans, catalyze prostaglandin production from arachidonic acid (1,2). While Cox1 expression is constitutive in most tissues, Cox2 expression is induced by lipopolysaccharide (LPS) and peptidoglycan (PGN) (3). PGN activates Ras, leading to phosphorylation of Raf at Ser338 and Erk1/2 at Tyr204. The activation of MAP kinase signaling results in subsequent activation of IKKα/β, phosphorylation of IκBα at Ser32/36, and NF-κB activation. Finally, activation of the transcription factor NF-κB is responsible for the induction of Cox2 expression (4). LPS and PGN induce the clinical manifestations of arthritis and bacterial infections, such as inflammation, fever, and septic shock (5), making Cox2 a useful target for therapeutic anti-inflammatory drugs (3). Cox1 and Cox2 also play a role in the neuropathology of Alzheimer's disease by potentiating γ-secretase activity and β-amyloid generation (6).
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant protein of human PTGS2.
- 亚型
- IgG
- Top Product
- Discover our top product PTGS2 Primary Antibody
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anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (AA 501-604) antibody
PTGS2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (AA 187-425) antibodyPTGS2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (AA 240-351) antibodyPTGS2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (AA 375-604) antibodyPTGS2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (AA 418-589) antibodyPTGS2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (C-Term) antibodyVerified PTGS2 适用: 人, 小鼠 WB, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) antibodyPTGS2 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (AA 363-391) antibodyPTGS2 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB17409 unconjugated
anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (AA 301-400) antibodyPTGS2 适用: 人, 小鼠, 大鼠, 绵羊 WB, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (AA 530-610) antibodyPTGS2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-1:4000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze/thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C.
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- 抗原
- PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2))
- 别名
- PTGS2 (PTGS2 产品)
- 别名
- COX-2 antibody, COX2 antibody, GRIPGHS antibody, PGG/HS antibody, PGHS-2 antibody, PHS-2 antibody, hCox-2 antibody, Cox-2 antibody, Pghs2 antibody, TIS10 antibody, Cox2 antibody, cox-2 antibody, CEF147 antibody, PGHS2 antibody, PHSII antibody, cox2 antibody, gripghs antibody, pgg/hs antibody, pghs-2 antibody, phs-2 antibody, PTGS2 antibody, hcox-2 antibody, fj02a10 antibody, ptgs2 antibody, unp1239 antibody, wu:fj02a10 antibody, zCOX-2 antibody, si:dkey-97o5.6 antibody, prostaglandin-endoperoxide synthase 2 antibody, prostaglandin G/H synthase 2 antibody, prostaglandin-endoperoxide synthase 2S homeolog antibody, prostaglandin-endoperoxide synthase 2a antibody, prostaglandin-endoperoxide synthase 2b antibody, PTGS2 antibody, Ptgs2 antibody, LOC100136456 antibody, ptgs2.S antibody, ptgs2 antibody, ptgs2a antibody, ptgs2b antibody
- 基因ID
- 5743
- UniProt
- P35354
- 途径
- Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
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