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- 抗原 See all LAMB2 抗体
- LAMB2 (Laminin, beta 2 (Laminin S) (LAMB2))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This LAMB2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 产品特性
- Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the unspliced form of the transcript than the spliced form. The full-length nature of the spliced transcript is not known.
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant protein of human LAMB2.
- 亚型
- IgG
- Top Product
- Discover our top product LAMB2 Primary Antibody
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anti-Laminin, beta 2 (Laminin S) (LAMB2) (AA 1498-1716) antibody
LAMB2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Laminin, beta 2 (Laminin S) (LAMB2) (AA 939-1129) antibodyLAMB2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Laminin, beta 2 (Laminin S) (LAMB2) (AA 1176-1309) antibodyLAMB2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Laminin, beta 2 (Laminin S) (LAMB2) antibodyLAMB2 适用: 人 WB, IHC (p) 宿主: 小鼠 Monoclonal CL2976 unconjugated
anti-Laminin, beta 2 (Laminin S) (LAMB2) (N-Term) antibodyLAMB2 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Laminin, beta 2 (Laminin S) (LAMB2) (AA 75-223) antibodyLAMB2 适用: 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Laminin, beta 2 (Laminin S) (LAMB2) (AA 1579-1606), (C-Term) antibodyLAMB2 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB20568 unconjugated
anti-Laminin, beta 2 (Laminin S) (LAMB2) antibodyLAMB2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Laminin, beta 2 (Laminin S) (LAMB2) (AA 1579-1798) antibodyLAMB2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Laminin, beta 2 (Laminin S) (LAMB2) (AA 1178-1311) antibodyLAMB2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze/thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C.
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- 抗原
- LAMB2 (Laminin, beta 2 (Laminin S) (LAMB2))
- 别名
- LAMB2 (LAMB2 产品)
- 别名
- LAMS antibody, NPHS5 antibody, AW211941 antibody, Lamb-2 antibody, Lams antibody, SLAM antibody, lamb1 antibody, lams antibody, LAMC1 antibody, laminin antibody, laminin subunit beta 2 antibody, laminin, beta 2 antibody, laminin subunit beta 2 L homeolog antibody, laminin, beta 2 (laminin S) antibody, LAMB2 antibody, Lamb2 antibody, lamb2.L antibody
- 基因ID
- 3913
- UniProt
- P55268
- 途径
- Skeletal Muscle Fiber Development
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