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CASR 抗体 (AA 926-1078)

Name: CASR 抗体 (AA 926-1078)
SKU: ABIN4886502
Availability: OutOfStock

CASR 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of CASR expression in HELA whole cell lysates ( Lane 1) and 22RV1 whole cell lysates ( Lane 2). (CASR 抗体 (AA 926-1078))

CASR was detected in paraffin-embedded sections of mouse kidney tissues using rabbit anti- CASR Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 ? (CASR 抗体 (AA 926-1078))

IHC

CASR was detected in paraffin-embedded sections of rat kidney tissues using rabbit anti- CASR Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 µg/mL. (CASR 抗体 (AA 926-1078))

IHC

3 images

(1 reference)

产品编号 ABIN4886502

发货至: 中国

Datasheet as PDF

抗原 See all CASR 抗体

CASR (Calcium-Sensing Receptor (CASR))
抗原表位
21

13

13

8

5

4

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1
AA 926-1078
适用
83

42

33

7

4

4

2

2

2

2

2

2

1
人, 小鼠, 大鼠
宿主
85

9
兔
Compatible Secondaries
克隆类型
87

7
多克隆
标记
36

8

7

5

3

3

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
This CASR antibody is un-conjugated
应用范围
70

30

19

16

14

9

7

5

4

2

1

1
Western Blotting (WB), Immunohistochemistry (IHC)

原理

Anti-Calcium Sensing Receptor/CASR Antibody Picoband®

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-Calcium Sensing Receptor/CASR Antibody Picoband® (ABIN4886502). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

E. coli-derived human CASR recombinant protein (Position: Q926-S1078). Human CASR shares 80.5% and 78.6% amino acid (aa) sequence identity with mouse and rat CASR, respectively.

亚型

IgG

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CASR 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Calcium-Sensing Receptor (CASR) (AA 121-220) antibody
CASR 适用: Pig WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Calcium-Sensing Receptor (CASR) (C-Term) antibody
CASR 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Calcium-Sensing Receptor (CASR) antibody
CASR 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Calcium-Sensing Receptor (CASR) (AA 216-229), (Extracellular) antibody
CASR 适用: 人 WB, IHC, IF, FACS, LCI, IC 宿主: 兔 Polyclonal unconjugated

anti-Calcium-Sensing Receptor (CASR) (AA 863-1079) antibody
CASR 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Calcium-Sensing Receptor (CASR) antibody
CASR 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Calcium-Sensing Receptor (CASR) (AA 260-287) antibody
CASR 适用: 小鼠 WB 宿主: 兔 Polyclonal RB41198 unconjugated

anti-Calcium-Sensing Receptor (CASR) (N-Term) antibody
CASR 适用: 人, 小鼠, 大鼠, Pig, Cow, 猴, 兔, Bat, 小鸡, 犬, Hamster, 马 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Calcium-Sensing Receptor (CASR) (AA 214-235) antibody
CASR 适用: 人, 小鼠, 大鼠, Pig, Cow, 猴, 兔, Bat, 小鸡, 犬, Hamster, 马 WB, IHC, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal ADD unconjugated

应用备注

Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Mouse, Rat, Human
Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Coburn JW, Elangovan L, Goodman WG, Fraza111 JM (Dec 1999). "Calcium-sensing receptor and calcimimetic agents". Kidney International. Supplement 73: S52-8. 2. D'Souza-Li L (Aug 2006). "The calcium-sensing receptor and related diseases". Arquivos Brasileiros De Endocrinologia E Metabologia 50 (4): 628-39. 3. Pidasheva S, Canaff L, Simonds WF, Marx SJ, Hendy GN (Jun 2005). "Impaired cotranslational processing of the calcium-sensing receptor due to signal peptide missense mutations in familial hypocalciuric hypercalcemia". Human Molecular Genetics 14 (12): 1679-90.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Yuan, Shi, Li, Yang, Tang, Hu, Du, Li, Gu, Wang, Xi, Tang: "Evaluation of a TPTX model induced by ischemia." in: Experimental animals, Vol. 66, Issue 4, pp. 345-356, (2018) (PubMed).
抗原

CASR (Calcium-Sensing Receptor (CASR))

别名

CASR (CASR 产品)

背景

Synonyms: Extracellular calcium-sensing receptor,CaSR,Parathyroid cell calcium-sensing receptor 1,PCaR1,CASR,GPRC2A, PCAR1,
Tissue Specificity: Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta. .
Background: The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

分子量

150 kDa

基因ID

846

UniProt

P41180

途径

Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis