~38 kDa, can run at up to 45 kDa on SDS-PAGE. 1 μg/mL of this antibody was sufficient for detection of Aha1 in 10 μg of Rat tissue lysate by colorimetric Immunoblot analysis using Goat anti-Rat IgG-HRP as the secondary antibody.
交叉反应 (详细)
Species reactivity (tested):Human, Mouse and Rat.
产品特性
Synonyms: C14orf3, HSPC322, Activator of 90 kDa heat shock protein ATPase homolog 1
ELISA. Western blot (1 μg/mL). Immunoprecipitation. Immunofluorescence. Immunocytochemistry. Immunohistochemitry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
限制
仅限研究用
浓度
1.59 mg/mL
缓冲液
0.02 M Potassium Phosphate, pH 7.2 containing 0.12 M Sodium Chloride
储存条件
4 °C/-20 °C
储存方法
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
有效期
12 months
抗原
AHSA1
(Activator of HSP90 ATPase Activity 1 (AHSA1))
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背景
Aha1 is a member of the Hsp90 cochaperone family, and is thought to stimulate Hsp90 ATPase activity by competing with p23 and other co-chaperones for Hsp90 binding (1, 2). It may affect a step in the endoplasmic reticulum to Golgi trafficking. Aha1 also interacts with HSPCA/Hsp90 and with the cytoplasmic tail of the vesicular stomatistis virus glycoproteins (VSV G) (3). Aha1 is expressed in numerous tissues, including the brain, heart, skeletal muscle, and kidney, and at low levels, the liver and placenta. Aha1 might be a potential therapeutic strategy to increase sensitivity to HSP inhibitors (4).Synonyms: Activator of 90 kDa heat shock protein ATPase homolog 1, C14orf3, HSPC322