This antibody detects Sphingosine Kinase 1 (pSer225). Antibody shows some cross reactivity (~10 % by ELISA) with other phosphoserine containing proteins.
纯化方法
Affinity chromatography
免疫原
A synthetic peptide incorporating the serine 225 phosphorylation site of mouse sphingosine kinase 1
Activation of Sphingosine kinase (Sphk) increases the bioactive lipid, sphingosine 1-phosphate (S1P) and has been observed in a variety of cancer cells. Phosphorylation of sphingosine by sphingosine kinase (Sphk) is the rate-limiting step in the cellular synthesis of S1P. A principle activation event is the phosphorylation of serine 225 of sphiongosine kinase 1. Inhibition of Sphk1 phosphorylation and hence, Sphk activity is an important target for the development of drugs for cancer, inflammation, cardioprotection as well as a many other indications.Synonyms: SPHK, SPK, SPK 1, SPK-1