Phospholipid-mediated signalling on neurons provokes diverse responses such as neurogenesis, pattern formation and neurite remodelling. A recently uncovered novel set of molecules in the mammalian brain, named plasticity-related genes (PRGs) mediate lipid phosphate phosphatase activity and provide evidence for their involvement in mechanisms of neuronal plasticity.Synonyms: EC 3.1.3.4, LPPR2, Lipid phosphate phosphatase-related protein type 2, PRG-4, PRG4, Plasticity-related gene 4 protein