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GPR19 抗体

GPR19 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN4620341
发货至: 中国
  • 抗原 See all GPR19 抗体
    GPR19 (G Protein-Coupled Receptor 19 (GPR19))
    适用
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    宿主
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    克隆类型
    • 33
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    多克隆
    标记
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    This GPR19 antibody is un-conjugated
    应用范围
    • 23
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    Western Blotting (WB)
    特异性
    This antibody reacts to G Protein-Coupled Receptor GPR4.
    纯化方法
    Affinity Purified
    免疫原
    Synthetic peptide derived from the GPR4 protein.
    亚型
    IgG
    Top Product
    Discover our top product GPR19 Primary Antibody
  • 应用备注
    Western Blot: 1: 400, Tissue lysate should be used at 10 - 50 g/lane.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 缓冲液
    Phosphate buffered saline with 0.08 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Ship on dry ice. Store (in aliquots) at -20 °C only.
  • 抗原
    GPR19 (G Protein-Coupled Receptor 19 (GPR19))
    Abstract
    GPR19 产品
    别名
    zgc:63912 antibody, G protein-coupled receptor 19 antibody, GPR19 antibody, Gpr19 antibody, gpr19 antibody
    背景
    Sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC) are bioactive lipid molecules involved in numerous biologicals processes. GPR4 shares sequence homology with OGR1 (51 % ), the highest of all GPCR's. GPR4 has been identified as another high affinity receptor for SPC and low affinity receptor for LPC. SPC and LPC stimulate kinase activation and DNA synthesis stimulated, both of which are pertussis toxin-sensitive, suggesting Gi-heterotrimeric G protein involvement. The GPR4 subfamily of GPCR's consists of four receptors that share significant sequence homology, OGR1, TDAG8 and G2A. G2A has been shown to be a potent transforming oncogene. GPR4 also malignantly transforms NIH3T3 cells and TDAG8 malignantly transforms the normal mammary epithelial cell line NMuMG. Overexpression of GPR4 or TDGA8 in HEK293 cells leads to transcriptional activation independent of exogenously added ligand. TDAG8 and GPR4 are also overexpressed in a range of human cancer tissues suggestive of a driving role in maintaining tumor formation.Synonyms: G-protein coupled receptor 19, G-protein coupled receptor 4
    基因ID
    2828
    NCBI登录号
    NP_005273
    UniProt
    P46093
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