GGCX
适用: 小鼠
ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC
宿主: 兔
Polyclonal
unconjugated
应用备注
Peptide ELISA: GGCX Antibody Detection limit dilution 1/32000. Western blot: 0.3-1 μg/mL. Approx 85 kDa band observed in Human Muscle lysates(calculated MW of 85 kDa according to NP_000812.2). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
限制
仅限研究用
浓度
0.5 mg/mL
缓冲液
Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项
Avoid repeated freezing and thawing.
储存条件
4 °C/-20 °C
储存方法
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Gamma-glutamyl carboxylase GGCX is an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis. Mutations in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor deficiency. GGCX accomplishes the posttranslational modification required for the activity of all of the vitamin K-dependent proteins (Wu et al., 1991 [PubMed 1749935]). These include some of the blood coagulation and anticoagulation proteins as well as bone gamma-carboxyglutamic acid (Gla) protein (BGLAP, MIM 112260) and bone matrix protein (MGP, MIM 154870).Synonyms: GC, Gamma-glutamyl carboxylase, Vitamin K gamma glutamyl carboxylase, Vitamin K-dependent gamma-carboxylase