CSNK1A1 抗体
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北京 101111
Quick Overview for CSNK1A1 抗体 (ABIN437965)
抗原
See all CSNK1A1 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人
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免疫原
- Human Casein Kinase 1 alpha protein.
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亚型
- IgY
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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储存条件
- -20 °C
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- CSNK1A1 (Casein Kinase 1, alpha 1 (CSNK1A1))
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背景
- The CKI family consists of several different genes, divided in alpha, beta, gamma, delta and epsilon, some of which are encoded by more than one gene. The single mammalian CK1 alpha gene can generate four different proteins by alterate transcription. CK1a was raised against the shortest of these proteins, and will therefore bind to all CK1 isotypes. The CK1 alpha proteins are involved in the control of protein degradation, and phosphorylate acidic regions of their substrate molecules. Typically the target ser/thr residues closely C-terminal to two or three aspartic or glutamic acid residues. Alternately, phosphorylation on residues 3 or 4 amino acids N-terminal to a ser/thr residue can also favor CKI phosphorylation. This means that CKI family enzymes often phosphorylate one or more ser/thr residues C-terminal to a phosphorylation site generated by the activity of another protein kinase.
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途径
- WNT signaling, Hedgehog Signaling
抗原
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