TIMELESS 抗体 (N-Term)
Quick Overview for TIMELESS 抗体 (N-Term) (ABIN410144)
抗原
See all TIMELESS 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- Reacts with human 138 kDa protein
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交叉反应
- 小鼠, 大鼠
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交叉反应 (详细)
- Cross reacts with proteins from mouse, rat and other species.
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纯化方法
- Antiserum
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免疫原
- Synthetic peptide derived from Nter domain of human hTIM protein
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亚型
- IgG
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应用备注
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Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
- IHC : 1/50 to 1/200 - WB : 1/100 to 1/1 000 -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Must be reconstituted in distilled water.
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储存条件
- 4 °C/-20 °C
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储存方法
- Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
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有效期
- 24 months
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- TIMELESS (Timeless Homolog (TIMELESS))
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别名
- Protein Timeless Homolog (hTIM)
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背景
- Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.
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UniProt
- Q9UNS1
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途径
- Protein targeting to Nucleus, Photoperiodism
抗原
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