TRAF2 抗体 (Internal Region)
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Quick Overview for TRAF2 抗体 (Internal Region) (ABIN401469)
抗原
See all TRAF2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- This antibody is directed against TRAF2 protein.
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交叉反应 （详细）
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Species reactivity (expected):Mouse.
Species reactivity (tested):Human. -
纯化方法
- Affinity chromatography
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免疫原
- Synthetic peptide corresponding to an internal region human TRAF2
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亚型
- IgG
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anti-TNF Receptor-Associated Factor 2 (TRAF2) (AA 1-300) antibody
TRAF2 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 2 (TRAF2) (AA 238-491) antibodyTRAF2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 2 (TRAF2) (C-Term) antibodyVerified TRAF2 适用: 人, 小鼠 WB, IHC, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 2 (TRAF2) (AA 39-188) antibodyTRAF2 适用: 人 IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 5C2C3 unconjugated
anti-TNF Receptor-Associated Factor 2 (TRAF2) antibodyTRAF2 适用: 人 WB, IHC, ELISA, IP, FACS 宿主: 兔 Monoclonal 9A5 unconjugated Recombinant Antibody
anti-TNF Receptor-Associated Factor 2 (TRAF2) (AA 39-188) antibodyTRAF2 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 4A12D9 unconjugated
anti-TNF Receptor-Associated Factor 2 (TRAF2) (AA 401-501) antibodyTRAF2 适用: 人 WB, ELISA, FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 2 (TRAF2) (AA 147-281) antibodyTRAF2 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 2 (TRAF2) (C-Term) antibodyTRAF2 适用: 人, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 2 (TRAF2) (N-Term) antibodyTRAF2 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/60,000 - 1/250,000. Western Blot: 1 μg/m. Immunohistochemistry. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.93 mg/mL (by UV absorbance at 280 nm)
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缓冲液
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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- TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))
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别名
- TRAF2 / TRAP3
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背景
- TRAF2, or Tumor Necrosis factor (TNF) Receptor-Associated Factor 2, is an adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Association to the receptor is also mediated by the interaction with TRADD. TRAF2 mediates activation of NF-kappa-B and MAPK8/JNK and is involved in apoptosis. TRAF2 forms a heterodimeric complex with TRAF1, which then recruits the inhibitor-of-apoptosis proteins (IAPs), apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2 for the inhibition of caspase activation. In this way it functions as a mediator of the anti-apoptotic signals from TNF receptors. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. TRAF2 may be involved in IL-15 signaling. Multiple alternatively spliced transcript variants exist, but the biological validity of only one transcript has been determined.Synonyms: TNF receptor-associated factor 2, Tumor necrosis factor type 2 receptor-associated protein 3
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基因ID
- 7186
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NCBI登录号
- NP_066961
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UniProt
- Q12933
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途径
- NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response, S100 Proteins
抗原
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