ATR 抗体 (Internal Region)
This anti-ATR antibody is a 兔 多克隆 antibody detecting ATR in WB 和 EIA. Suitable for 人, 小鼠, 犬, 鱼, 猴, 大鼠 和 非洲爪蟾.
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Quick Overview for ATR 抗体 (Internal Region) (ABIN401401)
抗原
See all ATR 抗体
ATR
(Ataxia Telangiectasia and Rad3 Related (ATR))
适用
人, 小鼠, 犬, 鱼, 猴, 大鼠, 非洲爪蟾
宿主
兔
克隆类型
多克隆
标记
This ATR antibody is un-conjugated
应用范围
Western Blotting (WB), Enzyme Immunoassay (EIA)
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抗原表位
- Internal Region
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特异性
- This antibody is specific for ATR protein.
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交叉反应 （详细）
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Species reactivity (expected):Mouse, Rat, Monkey, Canine, Fish, Xenopus.
Species reactivity (tested):Human. -
纯化方法
- Affinity chromatography
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免疫原
- Synthetic peptide corresponding to an internal region of human ATR protein
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亚型
- IgG
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anti-Ataxia Telangiectasia and Rad3 Related (ATR) (AA 2353-2644) antibody
ATR 适用: 人 WB, IP, ICC, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ataxia Telangiectasia and Rad3 Related (ATR) (Ser428) antibodyATR 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/15,000 - 1/70,000. Western Blot: 1/1,000 - 1/5,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.28 mg/mL (by UV absorbance at 280 nm)
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缓冲液
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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- ATR (Ataxia Telangiectasia and Rad3 Related (ATR))
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别名
- ATR / FRP1
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背景
- Ataxia Telangiectasia Mutated (ATM) and Rad 3-related protein (ATR) is a phosphatidylinositol kinase (PK)-related kinase which functions in response to DNA damage and repair as well as at DNA replication checkpoints during the cell cycle. ATR activates checkpoint signaling upon genotoxic stresses, such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. ATR is a member of the DNA-PK kinase family and is closely related to ATM and DNAPK for which DNA stimulates the observed kinase activity. Chromosomal remodeling proteins have also been reported to associate with ATR complexes, including histone deacetylases (HDAC1, HDAC2 and CHD4). ATR is known to phosphorylate BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and TP53/p53 which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. ATR is a nuclear protein, but can also be found in PML nuclear bodies in certain cell types. ATR is recruited to chromatin during Sphase and redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling.Synonyms: Ataxia telangiectasia and Rad3-related protein, FRAP-related protein 1, Serine/threonine-protein kinase ATR
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基因ID
- 545
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NCBI登录号
- NP_001175
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UniProt
- Q13535
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途径
- p53 Pathway, Apoptosis, DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus
抗原
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