PPP1R13B 抗体 (Internal Region)
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北京 101111
Quick Overview for PPP1R13B 抗体 (Internal Region) (ABIN401394)
抗原
See all PPP1R13B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- This antibody is directed against ASPP1.
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交叉反应 （详细）
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Species reactivity (expected):Mouse.
Species reactivity (tested):Human. -
纯化方法
- Affinity chromatography
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免疫原
- Synthetic peptide corresponding to an internal sequence of human ASPP1
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亚型
- IgG
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anti-Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B) antibody
PPP1R13B 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B) (AA 375-675) antibodyPPP1R13B 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B) (AA 1-90) antibodyPPP1R13B 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6H1 unconjugated
anti-Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B) (Internal Region) antibodyPPP1R13B 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B) (AA 900-949) antibodyPPP1R13B 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, Bat, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B) antibodyPPP1R13B 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B) (Middle Region) antibodyPPP1R13B 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/2,500 - 1/10,000. Western Blot: 1/500 - 1/3,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.3 mg/mL (by UV absorbance at 280 nm)
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缓冲液
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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- PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))
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别名
- PPP1R13B
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背景
- ASPP (ankyrin-repeat-, SH3-domain- proline-rich-region protein) proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins. ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis. In contrast, iASPP functionally inactivates p53. ASPPs may also regulate p63- and p73-mediated apoptosis. Both ASPP1 and 2 directly interact with p53 and specifically enhance the apoptotic function of p53 by stimulating its DNA binding and transactivation function on promoters of pro-apoptotic genes, such as Bax and PIG-3. Not all cell cycle arrest genes are affected, such as p21. Interestingly, expression of ASPP is frequently down-regulated in human breast carcinomas expressing wild-type p53 but not mutant p53. Therefore, ASPP might regulate the tumor suppression function of p53 in vivo.Synonyms: ASPP1, Apoptosis-stimulating of p53 protein 1, KIAA0771, Protein phosphatase 1 regulatory subunit 13B
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基因ID
- 23368
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NCBI登录号
- NP_056131
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UniProt
- Q96KQ4
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途径
- p53 Pathway
抗原
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