PTPN5 抗体 (N-Term)
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- 抗原 See all PTPN5 抗体
- PTPN5 (Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5))
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抗原表位
- AA 168-198, N-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PTPN5 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- 免疫原
- This STEP / PTPN5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-198 amino acids from the N-terminal region of human STEP / PTPN5.
- 克隆位点
- RB00604
- 亚型
- Ig Fraction
- Top Product
- Discover our top product PTPN5 Primary Antibody
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anti-Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5) (AA 270-533) antibody
PTPN5 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5) (AA 300-555) antibodyPTPN5 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5) (AA 360-490) antibodyPTPN5 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5) (AA 1-565) antibodyPTPN5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5) (AA 388-486) antibodyPTPN5 适用: 人 ELISA, IP 宿主: 小鼠 Monoclonal 2H5 unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5) (AA 57-74) antibodyPTPN5 适用: 人, 小鼠, 大鼠 WB 宿主: 小鼠 Monoclonal 23E5 unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5) (AA 331-558) antibodyPTPN5 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5) (AA 201-300) antibodyPTPN5 适用: 人, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5) (AA 388-486) antibodyPTPN5 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5) (AA 179-228) antibodyPTPN5 适用: 人, 小鼠, 大鼠, 犬, 斑马鱼, 豚鼠, 马, 兔, Cow, 猴, Pig, Bat, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
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- 抗原
- PTPN5 (Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5))
- 别名
- STEP / PTPN5 (PTPN5 产品)
- 别名
- STEP antibody, Step antibody, PTPSTEP antibody, protein tyrosine phosphatase, non-receptor type 5 antibody, ptpn5 antibody, PTPN5 antibody, Ptpn5 antibody
- 背景
- STEP (striatum-enriched phosphatase) is a neural-specific protein-tyrosine phosphatase, first isolated from the rat brain. The 537-amino acid predicted human protein as isolated from cDNA sequences is between 85 and 90 % identical to the mouse and rat sequences. In rat neuronal cell cultures, glutamate-mediated activation of N-methyl-D-aspartate (NMDA) receptors leads to the rapid but transient phosphorylation of extracellular signal-related kinase-2 (ERK2). NMDA-mediated influx of calcium, activates the calcium-dependent phosphatase calcineurin and the resulting dephosphorylation and activation of STEP. STEP then inactivatea ERK2 through tyrosine dephosphorylation and blocks translocation of the kinase to the nucleus. STEP plays a significant role in regulating the ERK activation and downstream signaling in neurons.
- 分子量
- 63538
- 基因ID
- 84867
- NCBI登录号
- NP_001035059, NP_001265165, NP_001265167, NP_001265168, NP_008837, NP_116170
- UniProt
- P54829
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