MAP2K4 抗体 (AA 235-264)
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Quick Overview for MAP2K4 抗体 (AA 235-264) (ABIN392418)
抗原
See all MAP2K4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 235-264
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预测反应
- Zf, X, M
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This MEK4(MAP2K4) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-264 amino acids from human MEK4(MAP2K4).
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亚型
- Ig Fraction
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应用备注
- WB: 1:1000. IHC-P: 1:10~50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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- MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))
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别名
- MEK4 (MAP2K4)
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背景
- MAP2K4 is a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. MAP2K4 is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.
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分子量
- 44288
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基因ID
- 6416
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NCBI登录号
- NP_001268364, NP_003001
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UniProt
- P45985
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途径
- MAPK Pathway, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling
抗原
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