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AD_K2 (AA 633-660), (C-Term) 抗体

适用: 人, 猴, 小鼠 WB 宿主: 兔 Polyclonal RB00896 unconjugated
产品编号 ABIN2841169
发货至: 中国
  • 抗原
    AD_K2
    抗原表位
    AA 633-660, C-Term
    适用
    人, 猴, 小鼠
    宿主
    • 1
    克隆类型
    • 1
    多克隆
    标记
    • 1
    非结合性
    应用范围
    Western Blotting (WB)
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This AD_K2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 633-660 amino acids from the C-terminal region of human AD_K2.
    克隆位点
    RB00896
    亚型
    Ig Fraction
  • 应用备注
    WB: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • Billard, Fitzhugh, Parker, Brozowski, McGinnis, Timoshchenko, Serafin, Lininger, Klauber-Demore, Sahagian, Truong, Sassano, Serody, Tarrant: "G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and Metastasis." in: PLoS ONE, Vol. 11, Issue 4, pp. e0152856, (2016) (PubMed).

    Rao, Rapoport, Kim: "Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients." in: The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), Vol. 12, Issue 6, pp. 851-60, (2009) (PubMed).

  • 抗原
    AD_K2
    背景
    The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the ADRBK2 enzyme, also known as GRK3, has 85 % amino acid similarity with ADRBK1, with the protein kinase catalytic domain having 95 % similarity. The ADRBK2 mRNA is approximately 8 kilobases with a distribution similar to that of ADRBK1. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
    分子量
    79710
    基因ID
    157
    NCBI登录号
    NP_005151
    UniProt
    P35626
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