This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
免疫原
This Parp6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 553-583 amino acids from the C-terminal region of human Parp6.
ARTD17 antibody, PARP-6-B1 antibody, PARP-6-C antibody, pART17 antibody, 1700119G14Rik antibody, 2310028P13Rik antibody, 3110038K10Rik antibody, C030013N01Rik antibody, PARP-6 antibody, RGD1310937 antibody, zgc:92798 antibody, poly(ADP-ribose) polymerase family member 6 antibody, poly (ADP-ribose) polymerase family, member 6 antibody, poly(ADP-ribose) polymerase family member 6 S homeolog antibody, poly [ADP-ribose] polymerase 6 antibody, poly (ADP-ribose) polymerase family, member 6a antibody, PARP6 antibody, Parp6 antibody, parp6 antibody, parp6.S antibody, LOC100475149 antibody, parp6a antibody
背景
Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.