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AGR2 抗体 (AA 95-124)

AGR2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB13858 unconjugated
产品编号 ABIN390227
发货至: 中国
  • 抗原 See all AGR2 抗体
    AGR2 (Anterior Gradient Homolog 2 (Xenopus Laevis) (AGR2))
    抗原表位
    • 16
    • 15
    • 11
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 95-124
    适用
    • 72
    • 40
    • 25
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    宿主
    • 79
    • 14
    • 1
    • 1
    • 1
    克隆类型
    • 73
    • 22
    多克隆
    标记
    • 45
    • 13
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    This AGR2 antibody is un-conjugated
    应用范围
    • 75
    • 41
    • 33
    • 20
    • 20
    • 14
    • 14
    • 13
    • 8
    • 4
    • 4
    • 4
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    预测反应
    Zf, M
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This AGR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-124 amino acids from the Central region of human AGR2.
    克隆位点
    RB13858
    亚型
    Ig Fraction
    Top Product
    Discover our top product AGR2 Primary Antibody
  • 应用备注
    WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • Guo, Chen, Zhu, Yu, Rong, Merugu, Mangukiya, Li: "A humanized monoclonal antibody targeting secreted anterior gradient 2 effectively inhibits the xenograft tumor growth." in: Biochemical and biophysical research communications, Vol. 475, Issue 1, pp. 57-63, (2017) (PubMed).

    Guo, Zhu, Yu, Merugu, Mangukiya, Smith, Li, Zhang, Negi, Rong, Cheng, Wu, Li: "Tumor-secreted anterior gradient-2 binds to VEGF and FGF2 and enhances their activities by promoting their homodimerization." in: Oncogene, Vol. 36, Issue 36, pp. 5098-5109, (2017) (PubMed).

  • 抗原
    AGR2 (Anterior Gradient Homolog 2 (Xenopus Laevis) (AGR2))
    别名
    Anterior Gradient 2 (AGR2) (AGR2 产品)
    别名
    AG2 antibody, GOB-4 antibody, HAG-2 antibody, PDIA17 antibody, XAG-2 antibody, Agr2h antibody, Gob-4 antibody, mAG-2 antibody, wu:fj29g05 antibody, zgc:112187 antibody, agr2 antibody, hag3 antibody, hag-3 antibody, bcmp11 antibody, MGC89004 antibody, XAgr2 antibody, agr2-A antibody, anterior gradient 2, protein disulphide isomerase family member antibody, anterior gradient 2 antibody, anterior gradient 3, protein disulphide isomerase family member antibody, anterior gradient 2, protein disulphide isomerase family member S homeolog antibody, AGR2 antibody, Agr2 antibody, agr2 antibody, agr3 antibody, agr2.S antibody
    背景
    Anterior gradient 2 (AGR2) is known as a cancer cell marker specifically up-regulated in response to depletion of serum and oxygen. AGR2 has been identified as a tumor marker in primary and secondary cancer lesions, and as a marker for detection of circulating tumor cells (CTCs). Elevated levels of AGR2 are known to increase the metastatic potential of cancer cells, but conditions leading to increased expression of AGR2 are not well understood.
    分子量
    19979
    基因ID
    10551
    NCBI登录号
    NP_006399
    UniProt
    O95994
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