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AGR2 抗体 (AA 95-124)

This anti-AGR2 antibody is a 兔 多克隆 antibody detecting AGR2 in WB 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN390227
发货至: 中国

Quick Overview for AGR2 抗体 (AA 95-124) (ABIN390227)

抗原

See all AGR2 抗体
AGR2 (Anterior Gradient Homolog 2 (Xenopus Laevis) (AGR2))

适用

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宿主

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克隆类型

  • 77
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多克隆

标记

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This AGR2 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB13858
  • 抗原表位

    • 28
    • 15
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    • 1
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    AA 95-124

    预测反应

    Zf, M

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This AGR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-124 amino acids from the Central region of human AGR2.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    有效期

    6 months
  • Guo, Chen, Zhu, Yu, Rong, Merugu, Mangukiya, Li: "A humanized monoclonal antibody targeting secreted anterior gradient 2 effectively inhibits the xenograft tumor growth." in: Biochemical and biophysical research communications, Vol. 475, Issue 1, pp. 57-63, (2017) (PubMed).

    Guo, Zhu, Yu, Merugu, Mangukiya, Smith, Li, Zhang, Negi, Rong, Cheng, Wu, Li: "Tumor-secreted anterior gradient-2 binds to VEGF and FGF2 and enhances their activities by promoting their homodimerization." in: Oncogene, Vol. 36, Issue 36, pp. 5098-5109, (2017) (PubMed).

  • 抗原

    AGR2 (Anterior Gradient Homolog 2 (Xenopus Laevis) (AGR2))

    别名

    Anterior Gradient 2 (AGR2)

    背景

    Anterior gradient 2 (AGR2) is known as a cancer cell marker specifically up-regulated in response to depletion of serum and oxygen. AGR2 has been identified as a tumor marker in primary and secondary cancer lesions, and as a marker for detection of circulating tumor cells (CTCs). Elevated levels of AGR2 are known to increase the metastatic potential of cancer cells, but conditions leading to increased expression of AGR2 are not well understood.

    分子量

    19979

    基因ID

    10551

    NCBI登录号

    NP_006399

    UniProt

    O95994
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