RAF1 抗体 (pSer43)
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北京 101111
Quick Overview for RAF1 抗体 (pSer43) (ABIN389730)
抗原
See all RAF1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pSer43
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预测反应
- B, M, Rat
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This RAF1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S43 of human RAF1.
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亚型
- Ig Fraction
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anti-V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1) (AA 31-130) antibody
RAF1 适用: 人 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1) (AA 190-350) antibodyRAF1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1) (AA 1-130) antibodyRAF1 适用: 人 WB, ELISA, PLA, RNAi 宿主: 小鼠 Monoclonal 1H4 unconjugated
anti-V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1) antibodyRAF1 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 4G4 unconjugated
anti-V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1) (pSer621) antibodyRAF1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1) (pSer259) antibodyRAF1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1) antibodyKD Validated RAF1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB2700 unconjugated Recombinant Antibody
anti-V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1) (AA 1-648) antibodyRAF1 适用: 人 WB, ELISA, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1) (pSer338) antibodyRAF1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1) antibodyRAF1 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- DB: 1:500
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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: "Type II cGMP-dependent protein kinase negatively regulates fibroblast growth factor signaling by phosphorylating Raf-1 at serine 43 in rat chondrosarcoma cells." in: Biochemical and biophysical research communications, Vol. 483, Issue 1, pp. 82-87, (2017) (PubMed).
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: "Type II cGMP-dependent protein kinase negatively regulates fibroblast growth factor signaling by phosphorylating Raf-1 at serine 43 in rat chondrosarcoma cells." in: Biochemical and biophysical research communications, Vol. 483, Issue 1, pp. 82-87, (2017) (PubMed).
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- RAF1 (V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1))
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别名
- RAF1
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背景
- Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.
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分子量
- 73052
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基因ID
- 5894
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NCBI登录号
- NP_002871
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UniProt
- P04049
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途径
- MAPK Pathway, RTK signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Stem Cell Maintenance, Hepatitis C, Autophagy, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling, BCR Signaling
抗原
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