Pan SUMO 抗体
适用: 人, 大鼠
IF, IHC (p), WB
宿主: 兔
Polyclonal
RB04602
unconjugated
(3 references)-
- 抗原
- Pan SUMO
- 适用
- 人, 大鼠
- 宿主
- 兔
- 克隆类型
- 多克隆
- 应用范围
- Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
- 纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- 免疫原
- "This Pan SUMO antibody recognizes SUMO2 and SUMO3. This antibody is generated from rabbits immunized with a recombinant protein encoding full length human SUMO3."
- 克隆位点
- RB04602
- 亚型
- Ig Fraction
-
- 应用备注
- IF: 1:10~50. WB: 1:1000. IHC-P: 1:100. IHC-P: 1:50~100
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
-
-
: "Ehrlichia chaffeensis exploits host SUMOylation pathways to mediate effector-host interactions and promote intracellular survival." in: Infection and immunity, Vol. 82, Issue 10, pp. 4154-68, (2014) (PubMed).
: "Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins identified through a string search." in: The Journal of biological chemistry, Vol. 287, Issue 50, pp. 42071-83, (2012) (PubMed).
: "Generation and nuclear translocation of sumoylated transmembrane fragment of cell adhesion molecule L1." in: The Journal of biological chemistry, Vol. 287, Issue 21, pp. 17161-75, (2012) (PubMed).
-
: "Ehrlichia chaffeensis exploits host SUMOylation pathways to mediate effector-host interactions and promote intracellular survival." in: Infection and immunity, Vol. 82, Issue 10, pp. 4154-68, (2014) (PubMed).
-
- 抗原
- Pan SUMO
- 背景
- Covalent modification of target lysines by SUMO (small ubiquitin-like modifier) modulates processes such as protein localization, transcription, nuclear transport, mitosis, DNA replication and repair, signal transduction, and viral reproduction. SUMO does not seem to be involved in protein degradation and may in fact function as an antagonist of ubiquitin in the degradation process. The SUMO family consists of SUMO1 and closely related homologs SUMO2, SUMO3, and SUMO4. Sumoylation has been shown to regulate a wide range of proteins, including MDM2, PIAS, PML, RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, Fas, Daxx, TNFRI, Topo-I, Topo-II, PARK2, WRN, Sp100, IkB-alpha, Androgen receptor (AR), GLUT1/4, CaMK, DNMT3B, TDG, HIF1A, CHD3, EXOSC9, RAD51, and viral targets such as CMV-IE1/2, EBV-BZLF1, and HPV/BPV-E1.
- 分子量
- 11637
- 基因ID
- 6612
- NCBI登录号
- NP_008867
- UniProt
- P55854
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