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ESRRG 抗体 (Internal Region)

ESRRG 适用: 人, 小鼠, 犬 WB 宿主: 山羊 Polyclonal unconjugated
产品编号 ABIN375117
发货至: 中国
  • 抗原 See all ESRRG 抗体
    ESRRG (Estrogen-Related Receptor gamma (ESRRG))
    抗原表位
    • 15
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    适用
    • 39
    • 38
    • 30
    • 12
    • 11
    • 11
    • 11
    • 9
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    人, 小鼠, 犬
    宿主
    • 49
    • 4
    • 1
    山羊
    克隆类型
    • 51
    • 3
    多克隆
    标记
    • 30
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This ESRRG antibody is un-conjugated
    应用范围
    • 36
    • 13
    • 13
    • 13
    • 13
    • 10
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    特异性
    This antibody reacts to ESRRG. This antibody is expected to recognise isoform 1.
    交叉反应 (详细)
    Species reactivity (expected):Mouse, Canine.
    Species reactivity (tested):Human.
    纯化方法
    Affinity chromatography
    免疫原
    Peptide with sequence CRMSNKDRHIDS, from the internal region of the protein sequence
    Top Product
    Discover our top product ESRRG Primary Antibody
  • 应用备注
    Peptide ELISA: 1/16000. Western Blot: 0.2 - 0.6 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    0,5 mg/mL
    缓冲液
    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    ESRRG (Estrogen-Related Receptor gamma (ESRRG))
    别名
    Estrogen-Related Receptor gamma (ESRRG 产品)
    别名
    ERR3 antibody, ERRgamma antibody, NR3B3 antibody, ESRRG antibody, USH2A antibody, DKFZp459J0417 antibody, err3 antibody, nr3b3 antibody, LOC100219115 antibody, errg antibody, errgamma antibody, esrrg antibody, errb/g antibody, esrrgl antibody, errbeta/gamma antibody, Errg antibody, mKIAA0832 antibody, estrogen related receptor gamma antibody, estrogen-related receptor gamma antibody, estrogen-related receptor gamma a antibody, estrogen-related receptor gamma b antibody, ESRRG antibody, esrrg antibody, Esrrg antibody, esrrga antibody, esrrgb antibody
    背景
    Estrogen related receptor (ERR gamma), a NR3 Steroid Receptor is an orphan member of the nuclear hormone receptor superfamily. All the ERR family members (1,2, and 3) share an almost identical DNA binding domain, which has 68 % amino acid identity with that of estrogen receptor. Studies involving the crystal structure of the LBD have shown a complex between ERR3 and SRC1. ERR gamma has been suggested to affect differentiation of the brain, heart, and kidney. ERR gamma binds as a monomer to an extended half site of the ERRE type (TCAAGGTCA). ERR gamma has been shown to interact with PGC1 alpha and has been implicated in the regulation of mitochondrial energy metabolism. In humans, ERR gamma pre mRNA undergoes extensive alternative splicing at the 5 prime end, yielding at least six mRNA splice variants and two protein isoforms that differ by 23 amino acids in the N terminus. ERR gamma has been shown to be overexpressed in breast tumors, and its expression is correlated with levels of ErbB4, a likely indicator of preferred clinical course. As a result, ERR gamma has been suggested to be a potential biomarker for favorable clinical course and, possibly, hormonal sensitivity, and as a candidate target for therapeutic development.Synonyms: ERR gamma-2, ERR3, ERRG2, ESRRG, Estrogen receptor-related protein 3, KIAA0832, NR3B3, Nuclear receptor subfamily 3 group B member 3
    基因ID
    2104, 9606
    UniProt
    P62508
    途径
    Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway
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