This antibody is expected to recognise isoform 1 (NP_005616.2 and NP_001007068.1) and isoform 3 (NP_001007070.1and NP_001007071.1) only.
交叉反应 (详细)
Species reactivity (expected):Mouse, Rat, Canine. Species reactivity (tested):Human.
纯化方法
Ammonium Sulphate precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
免疫原
Peptide with sequence from the N-Terminus of Human Syntenin-1 / SDCBP (NP_005616.2, NP_001007068.1, NP_001007069, NP_001007070.1, NP_001007071.1). Genename: SLEDLKVDKVIQAQ-C
Peptide ELISA: 1/128000. Western Blot: 0.01 - 0.03 μg/mL. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Syntenin is an approximately 33 kDa scaffolding protein that that binds to kainate receptor subunits via a PDZ interaction. Syntenin has a tightly regulated developmental profile in neurons and is most abundant in the period of intense growth and synapse formation and stabilization (Hirbec et al, 2005). There is extensive colocalization of syntenin and kainate receptors with particularly intense labeling for both proteins at growth cones. It is proposed that syntenin has a role both in controlling membrane organization and in determining the formation and maturation of synapses.Synonyms: MDA-9, MDA9, Melanoma differentiation-associated protein 9, Pro-TGF-alpha cytoplasmic domain-interacting protein 18, SYCL, Scaffold protein Pbp1, Syndecan-binding protein 1, TACIP18