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NPM1 抗体 (C-Term)

NPM1 适用: 人, 小鼠, 大鼠, 犬, Chimpanzee WB, EIA 宿主: 山羊 Polyclonal unconjugated
产品编号 ABIN374536
发货至: 中国
  • 抗原 See all NPM1 抗体
    NPM1 (Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1))
    抗原表位
    • 20
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    • 9
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    C-Term
    适用
    • 144
    • 105
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    • 13
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    • 3
    • 2
    • 1
    • 1
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    人, 小鼠, 大鼠, 犬, Chimpanzee
    宿主
    • 139
    • 26
    • 1
    • 1
    山羊
    克隆类型
    • 139
    • 29
    多克隆
    标记
    • 94
    • 15
    • 6
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    This NPM1 antibody is un-conjugated
    应用范围
    • 117
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    Western Blotting (WB), Enzyme Immunoassay (EIA)
    序列
    C-QEAIQDLWQW RKSL
    特异性
    This antibody recognizes Nucleophosmin.
    交叉反应 (详细)
    Species reactivity (expected):Canine, Bovine.
    Species reactivity (tested):Human, Mouse, Rat.
    纯化方法
    Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
    免疫原
    Peptide with sequence from the C Terminus of the protein sequence according to NP_002511.1, NP_954654.1.
    Top Product
    Discover our top product NPM1 Primary Antibody
  • 应用备注
    Peptide ELISA: 1/2000. Western Blot: 0.1 - 0.3 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Tris saline, pH ~7.3 containing 0.02 % Sodium Azide and 0.5 % BSA
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    NPM1 (Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1))
    别名
    Nucleophosmin (NPM1 产品)
    别名
    B23 antibody, NPM antibody, NO38 antibody, Npm antibody, B23NP antibody, npm4 antibody, npm antibody, CG7917 antibody, CRP1 antibody, Crp1 antibody, Dmel\\CG7917 antibody, dNLP antibody, dNLP-S antibody, p22 antibody, npm1 antibody, sb:cb487 antibody, nucleophosmin 1 antibody, nucleophosmin (nucleolar phosphoprotein B23, numatrin) L homeolog antibody, nucleophosmin 1b antibody, Nucleophosmin antibody, nucleophosmin antibody, nucleophosmin (nucleolar phosphoprotein B23, numatrin) antibody, Nucleoplasmin antibody, nucleophosmin 1a antibody, NPM1 antibody, Npm1 antibody, npm1.L antibody, npm1b antibody, npm antibody, Nlp antibody, npm1a antibody
    背景
    Nucleophosmin (NPM) also called B23, nutramin and NO38 is a ubiquitously expressed phosphoprotein involved in ribosome assembly/transport, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication, and regulation of p53. It is involved in the acute response of mammalian cells to environmental stress, such as UV rays. NPM continuously shuttles between the nucleus and cytoplasm. It has been shown to bind nucleic acid, prevent protein aggregation via its chaperone activities, protect enzymes during thermal denaturation, and facilitate renaturation of chemically denatured proteins. In its cellular structure role, there is evidence suggesting NPM is associated with the centrosome. It is the substrate of CDK2/cyclin E during duplication of centrosomes (cellular division). Because of NPM gene interaction with several tumor-associated chromosome translocations, NPM is thought to be a portion of several fusion proteins: NPM-ALK, NPM-RAR, and NPM-MLF1. While it is not thought to be part of the transforming potential of these fusion proteins, it is believed to act as the interface for oligomerization and oncogenic conversion of these tumor promoting fusion proteins.Synonyms: NPM, NPM1, Nucleolar Phosphoprotein B23, Nucleolar Protein NO38, Numatrin
    基因ID
    4869
    NCBI登录号
    NP_002511
    UniProt
    P06748
    途径
    Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
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