PAK1 抗体 (pThr402)
(1 reference)Quick Overview for PAK1 抗体 (pThr402) (ABIN372696)
抗原
See all PAK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pThr402
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特异性
- This antibody recognizes the ~68k to ~70k PAK protein phosphorylated at Thr402. The immunolabeling of PAK is completely eliminated by lambda-phosphatase treatment.
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交叉反应 （详细）
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Species reactivity (expected):Human, Bovine, Canine and Mouse.
Species reactivity (tested):Rat. -
纯化方法
- Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
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免疫原
- Phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr402 of Rat p21 activated kinase 2 (PAK-2).
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亚型
- IgG
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anti-P21-Activated Kinase 1 (PAK1) (AA 191-280) antibody
PAK1 适用: 人 WB, ELISA, IF, IHC (p), IP 宿主: 小鼠 Monoclonal 4D1 unconjugated
anti-P21-Activated Kinase 1 (PAK1) (Center) antibodyPAK1 适用: 人, 大鼠, 小鼠 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 1 (PAK1) (AA 252-501) antibodyPAK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 1 (PAK1) (pThr212) antibodyPAK1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 1 (PAK1) (AA 1-240) antibodyPAK1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 1 (PAK1) (AA 401-430) antibodyPAK1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 1 (PAK1) (Ser204) antibodyPAK1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 1 (PAK1) (AA 245-490) antibodyPAK1 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 1 (PAK1) (N-Term) antibodyPAK1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 1 (PAK1) (pThr423) antibodyPAK1 适用: 人 WB, IF 宿主: 兔 Polyclonal RB11381 unconjugated
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应用备注
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Western blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the antibody undiluted (in aliquots) at-20 °C.
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: "SAD-A potentiates glucose-stimulated insulin secretion as a mediator of glucagon-like peptide 1 response in pancreatic ? cells." in: Molecular and cellular biology, Vol. 33, Issue 13, pp. 2527-34, (2013) (PubMed).
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: "SAD-A potentiates glucose-stimulated insulin secretion as a mediator of glucagon-like peptide 1 response in pancreatic ? cells." in: Molecular and cellular biology, Vol. 33, Issue 13, pp. 2527-34, (2013) (PubMed).
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- PAK1 (P21-Activated Kinase 1 (PAK1))
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别名
- PAK1
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背景
- In mammals, there are several identified isoforms of p21-activated protein kinases or PAKs: alpha-PAK (also known as PAK-1) and beta-PAK (also known as PAK-3) are mostly brain-specific, while gamma-PAK (also known as PAK-2) is expressed ubiquitously (Jakobi et al., 2003). Mutations of the gene coding for PAK-3 are associated with X-linked mental retardation and recent work indicates that PAK-3 is a key regulator of synapse formation and plasticity in the hippocampus (Boda et al., 2004). PAK-3 is thought to play a key role in regulation of cell shape and motility as well as cell death (Jakobi et al., 2003, Walter et al., 1998). Autophosphorylation of Thr402 in the protein has been found to be essential for activation of PAK (Jakobi et al., 2000).Synonyms: Alpha-PAK, Beta-PAK, Gamma-PAK, OPHN3, Oligophrenin-3, PAK 1, PAK 2, PAK 3, PAK alpha, PAK beta, PAK gamma, PAK-1, PAK-2, PAK-3, PAK65, Serine/threonine-protein kinase PAK 1, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase PAK 3, p21-activated kinase 1, p21-activated kinase 2, p21-activated kinase 3, p58, p65-PAK
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基因ID
- 5058
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NCBI登录号
- NP_001122092
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UniProt
- Q13153
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途径
- MAPK Pathway, RTK signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Embryonic Body Morphogenesis
抗原
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