Collagen Type I 抗体
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- 抗原 See all Collagen Type I (COL1) 抗体
- Collagen Type I (COL1) (Collagen, Type I (COL1))
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适用
- 人, 小鼠, 哺乳动物, 鱼, 绵羊, Amphibian, Avian
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Collagen Type I antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- Specific for the ~140 kDa telopeptide portion of the Collagen I Alpha-1 polypeptide.
- 交叉反应 （详细）
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Species reactivity (expected):all Mammals, Birds and Amphibians.
Species reactivity (tested):Human, Mouse, Rat and Sheep. - 纯化方法
- Affinity Chromatography.
- 免疫原
- Peptide from the Human Collagen I Alpha-1 telopeptide sequence.
- 亚型
- IgG
- Top Product
- Discover our top product COL1 Primary Antibody
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anti-Collagen, Type I (COL1) antibody
COL1 适用: 人, 大鼠, 小鼠, Cow, 哺乳动物 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Collagen, Type I (COL1) antibodyCOL1 适用: 人 ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Collagen, Type I (COL1) (AA 1321-1400) antibodyCOL1 适用: 人, 大鼠, 小鼠, 兔, 犬, 鱼 WB, ELISA, IHC (fro), IHC (p), IF (p), IF (cc), FACS 宿主: 兔 Polyclonal unconjugated
anti-Collagen, Type I (COL1) (AA 1051-1150) antibodyCOL1 适用: 人, 大鼠, 小鼠, 兔 WB, ELISA, IHC (fro), IHC (p), IF (p), IF (cc), ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Collagen, Type I (COL1) antibody (FITC)COL1 适用: 人, 大鼠, 小鼠, Cow, 哺乳动物 WB, IHC, IP, FACS 宿主: 兔 Polyclonal FITC
anti-Collagen, Type I (COL1) antibody (Biotin)COL1 适用: 人, 大鼠, 小鼠, Cow, 哺乳动物 WB, ELISA, IHC, IP, FACS 宿主: 兔 Polyclonal Biotin
anti-Collagen, Type I (COL1) antibody (HRP)COL1 适用: 人, 大鼠, 小鼠, Cow, 哺乳动物 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal HRP
anti-Collagen, Type I (COL1) antibodyCOL1 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 小鼠 Monoclonal 3G3 unconjugated
anti-Collagen, Type I (COL1) antibodyCOL1 适用: 人, 大鼠, 小鼠 IHC (p), IF 宿主: 小鼠 Monoclonal 4H10 unconjugated
anti-Collagen, Type I (COL1) antibody (Biotin)COL1 适用: 人 ELISA 宿主: 山羊 Polyclonal Biotin
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- 应用备注
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Western Blot: 1/1000. Immunohistochemitry: 1/100. The antibody works well for Immunohistochemistry on Paraformaldehyde-Fixed Sectionswith a simple antigen-retrieval protocol (incubate slides for 20 minutes at 90 °C in 10 mMsodium citrate ( pH 6.0)/ 0.1 % Tween-20). Note that in paraffin sections ofFormaldehyde-Fixed fibrotic mouse lung tissue, the antibody recognizes mature collagen Ithat has formed fibrils in the extracellular matrix.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS without preservatives.
- 储存液
- Without preservative
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- -20 °C
- 储存方法
- Store the antibody undiluted (in aliquots) at-20 °C.
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- 抗原
- Collagen Type I (COL1) (Collagen, Type I (COL1))
- 别名
- Collagen Type I (COL1 产品)
- 别名
- collagen type III alpha 1 chain antibody, COL3A1 antibody
- 背景
- Collagen is the most abundant protein in mammals with type 1 collagen being the most abundant of the 29 known collagens. Type 1 collagen is integral in the strengthening and structural support of many tissues including skin, tendon, artery walls, fibrocartilage, bone and teeth. Collagens are synthesized with N-terminal and C-terminal propeptides that are cleaved during maturation and secretion. After cleavage of the propeptides, the most N-terminal and C-terminal remaining sequences are known as telopeptides. Mutations in the collagen 1, alpha 1 gene (COL1A1) are known to cause osteogenesis imperfecta (aka brittle bone disease) (Byers 1989). Furthermore, mutations found in the fist 90 residues of the helical region of alpha 1 collagen have been implicated in the prevention or delayed removal of the procoallagen N-propeptide leading to a combined osteogenesis imperfecta and Ehlers-Danlos syndrome (EDS) phenotype (Cabral et al., 2005).Synonyms: Alpha-1 type I collagen, Alpha-2 type I collagen, COL1A1, COL1A2
- 基因ID
- 1277
- NCBI登录号
- NP_000079
- UniProt
- P02452
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