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Collagen Type I 抗体

Name: Collagen Type I 抗体
Brand: antibodies-online
SKU: ABIN135046
Availability: OutOfStock

This 山羊多克隆 antibody specifically detects Collagen Type I in WB, ELISA, IHC (fro), IP, ICC, IHC (p), FACS 和 IEM. It exhibits reactivity toward 人, 小鼠, 大鼠, Cow, 兔, 犬, 绵羊, 小鸡, Pig, Hamster, Cat, 豚鼠, Elephant, Chinchilla chinchilla 和 Tree shrew. It has been mentioned in 69+ publications

Decreases in the levels of activated HSC markers, SOX9, COL1 and phosphoMyl9 (PMYL9) following PAK-1 abrogation by siRNA1 in activated rat HSCs relative to their respective scrambled control levels. (Collagen Type I 抗体)

Characterisation of COL1 expression in control and Sox9-null animals following liver fibrosis induction using ABIN135046. (Collagen Type I 抗体)

IHC

Activated mouse HSCs (‘Control') show decreased protein levels for α-SMA, COL1 and SOX9 by immunoblotting following the loss of integrin beta-1 (‘Itgb1-null'). (Collagen Type I 抗体)

Elevated collagen levels in skeletal muscles in SGCA- and SGCD-null mice and in the heart of SGCD-null mice investigated using ABIN135046: Immunofluorescent images of skeletal muscles stained with collagen type I (fibrotic marker, green) and laminin (extracellular matrix of muscle fibres, red) Scale bar: 100 μm. (Collagen Type I 抗体)

Immunofluorescence images of the heart stained with collagen type I (fibrotic marker, green) using ABIN135046. (Collagen Type I 抗体)

(A) Effects on collagen deposition in indirect (inserts) and direct coculture of human dermal fibroblasts and siRNA-treated THP1 cells. (Collagen Type I 抗体)

Immunoblot analysis of primary AF and NP cell lysates from two independent donors, D1 (P0) and D3 (P1), respectively, for COL1A1 (ABIN135046) and COL2A1 (ABIN135048). (Collagen Type I 抗体)

Immunoblot Analysis using ABIN135046. (Collagen Type I 抗体)

8 images

(69 references)

产品编号 ABIN135046

发货至: 中国

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Quick Overview for Collagen Type I 抗体 (ABIN135046)

抗原

See all Collagen Type I (COL1) 抗体

Collagen Type I (COL1) (Collagen, Type I (COL1))

适用

人, 小鼠, 大鼠, Cow, 兔, 犬, 绵羊, 小鸡, Pig, Hamster, Cat, 豚鼠, Elephant, Chinchilla chinchilla, Tree shrew

宿主

山羊

克隆类型

多克隆

标记

This Collagen Type I antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunoelectron Microscopy (IEM)

原理

Goat Anti-Type I Collagen-UNLB

特异性

Reacts with conformational determinants on type I collagen Referenced species reactivities include - Human 1-5,10,20,26,27,29,31-34 Chicken 17 Hamster 11,18 Mouse 24,27,28 Chinchilla 19 Porcine 5,21 Rat 5,13-15,23,25,27,35 Elephant 8 Rabbit 16,30 Bovine 6,20 Feline 9 Sheep 7 Canine 5,12 Guinea Pig 16 Tree Shrew 22

交叉反应（详细）

Exhibits < 10 % cross reactivity with collagen type II, III, IV, V and VI. The antibody has not been tested for reactivity with other ECM proteins (e.g., laminin, fibronectin).

产品特性

Purified Anti-Type I Collagen antibody for use in ELISA, immunohistochemistry / immunocytochemistry, electron microscopy, flow cytometry, western blotting, and immunoprecipitation assays.

纯化方法

Purified by affinity chromatography on type I collagen covalently linked to agarose, cross-adsorbed against Collagen types II, III, IV, V, and VI for minimal reactivity

免疫原

Type I collagen

亚型

IgG
anti-Collagen, Type I (COL1) (AA 1321-1400) antibody
COL1 适用: 人, 小鼠, 大鼠, 兔, 犬, 鱼 WB, ELISA, IHC (fro), IHC (p), IF (cc), IF (p), FACS 宿主: 兔 Polyclonal unconjugated

anti-Collagen, Type I (COL1) (AA 1051-1150) antibody
COL1 适用: 人, 小鼠, 大鼠, 兔 WB, ELISA, IHC (fro), ICC, IHC (p), IF (cc), IF (p), FACS 宿主: 兔 Polyclonal unconjugated

anti-Collagen, Type I (COL1) antibody
COL1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 小鼠 Monoclonal 4H10 unconjugated

anti-Collagen, Type I (COL1) antibody (Biotin)
COL1 适用: 人, 小鼠, 大鼠, Cow, 兔, 犬, 绵羊, 小鸡, Pig, Hamster, Cat, 豚鼠, Elephant, Chinchilla chinchilla, Tree shrew WB, ELISA, IHC (fro), IP, ICC, IHC (p), FACS, IEM 宿主: 山羊 Polyclonal Biotin

anti-Collagen, Type I (COL1) antibody
COL1 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 小鼠 Monoclonal 3G3 unconjugated

anti-Collagen, Type I (COL1) (AA 1051-1150) antibody (FITC)
COL1 适用: 人, 小鼠, 大鼠, 兔 WB, IF (cc), IF (p), FACS 宿主: 兔 Polyclonal FITC

anti-Collagen, Type I (COL1) (AA 1051-1150) antibody (AbBy Fluor® 488)
COL1 适用: 人, 小鼠, 大鼠, 兔 WB, IF (cc), IF (p), FACS 宿主: 兔 Polyclonal AbBy Fluor® 488

anti-Collagen, Type I (COL1) (AA 1200-1217) antibody
COL1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Collagen, Type I (COL1) antibody (FITC)
COL1 适用: 人, 小鼠, 大鼠, Cow, 兔, 犬, 绵羊, 小鸡, Pig, Hamster, Cat, 豚鼠, Elephant, Chinchilla chinchilla, Tree shrew WB, IHC (fro), ICC, IHC (p), FACS, FLISA 宿主: 山羊 Polyclonal FITC

anti-Collagen, Type I (COL1) antibody (Biotin)
COL1 适用: 人 ELISA, IHC (fro) 宿主: 小鼠 Monoclonal 4F6 Biotin

应用备注

Optimal working dilution should be determined by the investigator.

说明

Pooled antisera from goats hyperimmunized with type I collagen

限制

仅限研究用
状态

Liquid

浓度

0.4 mg/mL

缓冲液

Borate buffered saline, pH 8.2

储存条件

4 °C

储存方法

2-8°C
Corciulo, Castro, Coughlin, Jacob, Li, Fenyö, Rifkin, Kennedy, Cronstein: "Intraarticular injection of liposomal adenosine reduces cartilage damage in established murine and rat models of osteoarthritis." in: Scientific reports, Vol. 10, Issue 1, pp. 13477, (2020) (PubMed).

Bujor, El Adili, Parvez, Marden, Trojanowska: "Fli1 Downregulation in Scleroderma Myeloid Cells Has Profibrotic and Proinflammatory Effects." in: Frontiers in immunology, Vol. 11, pp. 800, (2020) (PubMed).

Becker, OConnell, Vo, Cain, Tampe, Bizarro, Sugimoto, McGow, Asara, Lovisa, McAndrews, Zielinski, Lorenzi, Zeisberg, Raza, LeBleu, Kalluri: "Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer." in: Cell reports, Vol. 31, Issue 9, pp. 107701, (2020) (PubMed).

Wietecha, Pensalfini, Cangkrama, Müller, Jin, Brinckmann, Mazza, Werner: "Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds." in: Nature communications, Vol. 11, Issue 1, pp. 2604, (2020) (PubMed).

Bigaeva, Puerta Cavanzo, Stribos, de Jong, Biel, Mutsaers, Jensen, Nørregaard, Leliveld, de Jong, Hillebrands, van Goor, Boersema, Bank, Olinga: "Predictive Value of Precision-Cut Kidney Slices as an Ex Vivo Screening Platform for Therapeutics in Human Renal Fibrosis." in: Pharmaceutics, Vol. 12, Issue 5, (2020) (PubMed).

Fried, Gilboa, Har-Zahav, Lavrut, Du, Karjoo, Russo, Shamir, Wells, Waisbourd-Zinman: "Extrahepatic cholangiocyte obstruction is mediated by decreased glutathione, Wnt and Notch signaling pathways in a toxic model of biliary atresia." in: Scientific reports, Vol. 10, Issue 1, pp. 7599, (2020) (PubMed).

Koopmans, Hesse, Nawijn, Kumawat, Menzen, Sophie T Bos, Smits, Bakker, van den Berge, Koppelman, Guryev, Gosens: "Smooth-muscle-derived WNT5A augments allergen-induced airway remodelling and Th2 type inflammation." in: Scientific reports, Vol. 10, Issue 1, pp. 6754, (2020) (PubMed).

Cui, Zhang, Leng, Blokzijl, Jansen, Dijkstra, Faber: "Pirfenidone Inhibits Cell Proliferation and Collagen I Production of Primary Human Intestinal Fibroblasts." in: Cells, Vol. 9, Issue 3, (2020) (PubMed).

Hreha, Collins, Daugherty, Twentyman, Paluri, Hunstad: "TGF��1 orchestrates renal fibrosis following Escherichia coli pyelonephritis." in: Physiological reports, Vol. 8, Issue 6, pp. e14401, (2020) (PubMed).

Wilson, Jarman, Mellin, Wilson, Waddell, Tsokkou, Younger, Raven, Bhalla, Noll, Olde Damink, Schaap, Chen, Bates, Banales, Dean, Henderson, Sansom, Kendall, Boulter: "Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors." in: Nature communications, Vol. 11, Issue 1, pp. 445, (2020) (PubMed).

Kawakubo, Tanaka, Ochi, Watanabe, Saka-Tanaka, Kanamori, Yoshioka, Yamashita, Goto, Itoh, Shirakawa, Kanai, Suzuki, Sawada, Ito, Ishigami, Fujishiro, Arima, Ogawa, Suganami: "Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis-associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects." in: Scientific reports, Vol. 10, Issue 1, pp. 983, (2020) (PubMed).

Ke, Yuan, Qin, Shi, Luo, Fang, Xu, Sun, Zen, Jiang, Zhou, Yang: "UCP2-induced hypoxia promotes lipid accumulation and tubulointerstitial fibrosis during ischemic kidney injury." in: Cell death & disease, Vol. 11, Issue 1, pp. 26, (2020) (PubMed).

Gasparitsch, Schieber, Schaubeck, Keller, Cattaruzza, Lange-Sperandio: "Tyrphostin AG490 reduces inflammation and fibrosis in neonatal obstructive nephropathy." in: PLoS ONE, Vol. 14, Issue 12, pp. e0226675, (2020) (PubMed).

Dobie, Wilson-Kanamori, Henderson, Smith, Matchett, Portman, Wallenborg, Picelli, Zagorska, Pendem, Hudson, Wu, Budas, Breckenridge, Harrison, Mole, Wigmore, Ramachandran, Ponting, Teichmann, Marioni et al.: "Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis. ..." in: Cell reports, Vol. 29, Issue 7, pp. 1832-1847.e8, (2020) (PubMed).

Boland, Oró, Tølbøl, Thrane, Nielsen, Cohen, Tabor, Fernandes, Tovchigrechko, Veidal, Warrener, Sellman, Jelsing, Feigh, Vrang, Trevaskis, Hansen: "Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source." in: World journal of gastroenterology, Vol. 25, Issue 33, pp. 4904-4920, (2020) (PubMed).

Verhaart, Putker, van de Vijver, Tanganyika-de Winter, Pasteuning-Vuhman, Plomp, Aartsma-Rus, van Putten: "Cross-sectional study into age-related pathology of mouse models for limb girdle muscular dystrophy types 2D and 2F." in: PLoS ONE, Vol. 14, Issue 8, pp. e0220665, (2020) (PubMed).

Birket, Raibaud, Lettieri, Adamson, Letang, Cervello, Redon, Ret, Viale, Wang, Biton, Guillemot, Mikol, Leonard, Hanley, Orsini, Itier: "A Human Stem Cell Model of Fabry Disease Implicates LIMP-2 Accumulation in Cardiomyocyte Pathology." in: Stem cell reports, Vol. 13, Issue 2, pp. 380-393, (2020) (PubMed).

Ling, Li, Wang, Meng, Li, Zhang: "Carvedilol improves liver cirrhosis in rats by inhibiting hepatic stellate cell activation, proliferation, invasion and collagen synthesis." in: Molecular medicine reports, Vol. 20, Issue 2, pp. 1605-1612, (2020) (PubMed).

Del Campo, Sánchez-López, Salaices, von Kleeck, Expósito, González-Gómez, Cussó, Guzmán-Martínez, Ruiz-Cabello, Desco, Assoian, Briones, Andrés: "Vascular smooth muscle cell-specific progerin expression in a mouse model of Hutchinson-Gilford progeria syndrome promotes arterial stiffness: Therapeutic effect of dietary nitrite." in: Aging cell, Vol. 18, Issue 3, pp. e12936, (2020) (PubMed).

Marchetti, Burwell, Peterson, Cann, Hanna, Li, Ongstad, Boyd, Kennedy, Zhao, Rickert, Grimsby, DallAcqua, Wu, Tsui, Borrok, Gupta: "Targeted drug delivery via caveolae-associated protein PV1 improves lung fibrosis." in: Communications biology, Vol. 2, pp. 92, (2020) (PubMed).

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抗原

Collagen Type I (COL1) (Collagen, Type I (COL1))

别名

TypeI Collagen

背景

Description: Goat Anti-Type I Collagen-UNLB
NCBI_Official_Symbol: COL1A1, COL1A2
Synoynms: COL1

基因ID

1277

UniProt

P02452

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Collagen Type I 抗体

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Quick Overview for Collagen Type I 抗体 (ABIN135046)

抗原

适用

宿主

克隆类型

标记

应用范围