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Collagen Type I 抗体

This anti-Collagen Type I antibody is a 兔 多克隆 antibody detecting Collagen Type I in WB 和 IHC (p). Suitable for 人, 小鼠, 哺乳动物, 鱼, 绵羊, Amphibian 和 Avian.
产品编号 ABIN372600
发货至: 中国

Quick Overview for Collagen Type I 抗体 (ABIN372600)

抗原

See all Collagen Type I (COL1) 抗体
Collagen Type I (COL1) (Collagen, Type I (COL1))

适用

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人, 小鼠, 哺乳动物, 鱼, 绵羊, Amphibian, Avian

宿主

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克隆类型

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多克隆

标记

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This Collagen Type I antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 特异性

    Specific for the ~140 kDa telopeptide portion of the Collagen I Alpha-1 polypeptide.

    交叉反应 (详细)

    Species reactivity (expected):all Mammals, Birds and Amphibians.
    Species reactivity (tested):Human, Mouse, Rat and Sheep.

    纯化方法

    Affinity Chromatography.

    免疫原

    Peptide from the Human Collagen I Alpha-1 telopeptide sequence.

    亚型

    IgG
  • 应用备注

    Western Blot: 1/1000. Immunohistochemitry: 1/100. The antibody works well for Immunohistochemistry on Paraformaldehyde-Fixed Sectionswith a simple antigen-retrieval protocol (incubate slides for 20 minutes at 90 °C in 10 mMsodium citrate ( pH 6.0)/ 0.1 % Tween-20). Note that in paraffin sections ofFormaldehyde-Fixed fibrotic mouse lung tissue, the antibody recognizes mature collagen Ithat has formed fibrils in the extracellular matrix.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS without preservatives.

    储存液

    Without preservative

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C

    储存方法

    Store the antibody undiluted (in aliquots) at-20 °C.
  • 抗原

    Collagen Type I (COL1) (Collagen, Type I (COL1))

    别名

    Collagen Type I

    背景

    Collagen is the most abundant protein in mammals with type 1 collagen being the most abundant of the 29 known collagens. Type 1 collagen is integral in the strengthening and structural support of many tissues including skin, tendon, artery walls, fibrocartilage, bone and teeth. Collagens are synthesized with N-terminal and C-terminal propeptides that are cleaved during maturation and secretion. After cleavage of the propeptides, the most N-terminal and C-terminal remaining sequences are known as telopeptides. Mutations in the collagen 1, alpha 1 gene (COL1A1) are known to cause osteogenesis imperfecta (aka brittle bone disease) (Byers 1989). Furthermore, mutations found in the fist 90 residues of the helical region of alpha 1 collagen have been implicated in the prevention or delayed removal of the procoallagen N-propeptide leading to a combined osteogenesis imperfecta and Ehlers-Danlos syndrome (EDS) phenotype (Cabral et al., 2005).Synonyms: Alpha-1 type I collagen, Alpha-2 type I collagen, COL1A1, COL1A2

    基因ID

    1277

    NCBI登录号

    NP_000079

    UniProt

    P02452
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