我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

H2AFX 抗体 (AA 137-141)

Name: H2AFX 抗体 (AA 137-141)
SKU: ABIN362952
Availability: OutOfStock

Cited in 5+ publications. This anti-H2AFX antibody is a 兔多克隆 antibody detecting H2AFX in WB, IHC 和 IF. Suitable for 人.

(5 references)

产品编号 ABIN362952

发货至: 中国

Contact our Customer Service for availability and price in your country. Contact Info

Our Local Distributor

中国
北京 101111

No. 88 KeChuang 6th Street

Beijing Economic Technological Development Area

Room 801-803

4A Biotech Co.,Ltd.

Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for H2AFX 抗体 (AA 137-141) (ABIN362952)

抗原

See all H2AFX 抗体

H2AFX (H2A Histone Family, Member X (H2AFX))

适用

人

宿主

兔

克隆类型

多克隆

标记

This H2AFX antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Discover our top product H2AFX Primary Antibody

抗原表位
43

21

18

10

5

5

5

5

3

3

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 137-141

特异性

The antibody detects endogenous level of total Histone H2A.X protein.

纯化方法

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.

免疫原

Peptide sequence around AA 137-141 (Q-A-S-Q-E) derived from Human Histone H2A.X. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

亚型

IgG
anti-H2A Histone Family, Member X (H2AFX) (AA 115-143), (C-Term) antibody
H2AFX 适用: 人 WB, IHC (p) 宿主: 小鼠 Monoclonal 938CT5-1-1 unconjugated

anti-H2A Histone Family, Member X (H2AFX) (ubLys119) antibody
H2AFX 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-H2A Histone Family, Member X (H2AFX) (pSer140) antibody
H2AFX 适用: 人 WB, ELISA, ICC, IHC (p), FACS, IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-H2A Histone Family, Member X (H2AFX) antibody
H2AFX 适用: 人 WB, IHC (p) 宿主: 小鼠 Monoclonal 8C5 unconjugated

anti-H2A Histone Family, Member X (H2AFX) (H2AXS139ph) antibody
H2AFX 适用: 人 WB, ELISA, IF, ChIP 宿主: 兔 Polyclonal unconjugated

anti-H2A Histone Family, Member X (H2AFX) antibody
H2AFX 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 23GB6040 unconjugated Recombinant Antibody

anti-H2A Histone Family, Member X (H2AFX) (H2A.XS139ph) antibody
H2AFX 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-H2A Histone Family, Member X (H2AFX) (pSer139) antibody
H2AFX 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-H2A Histone Family, Member X (H2AFX) (C-Term) antibody
H2AFX 适用: 人 WB, IF, ICC, ChIP 宿主: 兔 Polyclonal unconjugated

anti-H2A Histone Family, Member X (H2AFX) (pTyr143) antibody
H2AFX 适用: 人, 小鼠, 大鼠 ELISA, ICC, IHC (p), FACS, IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

应用备注

Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
Immunofluorescence: 1:100-1:200

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C/-20 °C

储存方法

Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Qing, Liang, Du, Fan, Xu, Xu, Shi: "Apoptosis induced by trimethyltin chloride in human neuroblastoma cells SY5Y is regulated by a balance and cross-talk between NF-κB and MAPKs signaling pathways." in: Archives of toxicology, Vol. 87, Issue 7, pp. 1273-85, (2013) (PubMed).

Li, Hu, He, Li, Zhu, Hou, Zhang, Li, Zhang, Wang, Liu, Yao, Zhang: "Up-regulation of NDRG2 through nuclear factor-kappa B is required for Leydig cell apoptosis in both human and murine infertile testes." in: Biochimica et biophysica acta, Vol. 1822, Issue 2, pp. 301-13, (2012) (PubMed).

Li, Kikuchi, Zheng, Noguchi, Takahashi, Nishida, Masuda, Yang, Takano: "Downregulation and translocation of nuclear ING4 is correlated with tumorigenesis and progression of head and neck squamous cell carcinoma." in: Oral oncology, Vol. 47, Issue 3, pp. 217-23, (2011) (PubMed).

Li, Nishida, Noguchi, Zheng, Takahashi, Yang, Masuda, Takano: "Decreased nuclear expression and increased cytoplasmic expression of ING5 may be linked to tumorigenesis and progression in human head and neck squamous cell carcinoma." in: Journal of cancer research and clinical oncology, Vol. 136, Issue 10, pp. 1573-83, (2010) (PubMed).

Dickey, Redon, Nakamura, Baird, Sedelnikova, Bonner: "H2AX: functional roles and potential applications." in: Chromosoma, Vol. 118, Issue 6, pp. 683-92, (2009) (PubMed).
抗原

H2AFX (H2A Histone Family, Member X (H2AFX))

别名

Histone H2A.X

背景

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation

分子量

15 kDa

NCBI登录号

NP_002096

UniProt

P16104

途径

Telomere Maintenance, DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus