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H2AFX 抗体 (AA 137-141)

Name: H2AFX 抗体 (AA 137-141)
SKU: ABIN362952
Availability: OutOfStock

This anti-H2AFX antibody is a 兔多克隆 antibody detecting H2AFX in WB, IHC 和 IF. Suitable for 人. This Primary Antibody has been cited in 5+ publications.

(5 references)

产品编号 ABIN362952

发货至: 中国

Quick Overview for H2AFX 抗体 (AA 137-141) (ABIN362952)

抗原

See all H2AFX 抗体

H2AFX (H2A Histone Family, Member X (H2AFX))

适用

人

宿主

兔

克隆类型

多克隆

标记

This H2AFX antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Discover our top product H2AFX Primary Antibody

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AA 137-141

特异性

The antibody detects endogenous level of total Histone H2A.X protein.

纯化方法

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.

免疫原

Peptide sequence around AA 137-141 (Q-A-S-Q-E) derived from Human Histone H2A.X. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

亚型

IgG
anti-H2A Histone Family, Member X (H2AFX) (AA 115-143), (C-Term) antibody
H2AFX 适用: 人 WB, IHC (p) 宿主: 小鼠 Monoclonal 938CT5-1-1 unconjugated

anti-H2A Histone Family, Member X (H2AFX) (pSer140) antibody
H2AFX 适用: 人 WB, ELISA, IHC (p), ICC, FACS, IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-H2A Histone Family, Member X (H2AFX) (ubLys119) antibody
H2AFX 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), ICC, IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-H2A Histone Family, Member X (H2AFX) antibody
H2AFX 适用: 人 WB, IHC (p) 宿主: 小鼠 Monoclonal 8C5 unconjugated

anti-H2A Histone Family, Member X (H2AFX) (pSer139) antibody
H2AFX 适用: 人 WB, ELISA, IF, ChIP 宿主: 兔 Polyclonal unconjugated

anti-H2A Histone Family, Member X (H2AFX) (pSer139) antibody
H2AFX 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-H2A Histone Family, Member X (H2AFX) (pSer139) antibody
H2AFX 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-H2A Histone Family, Member X (H2AFX) (C-Term) antibody
H2AFX 适用: 人 WB, IF, ICC, ChIP 宿主: 兔 Polyclonal unconjugated

anti-H2A Histone Family, Member X (H2AFX) (pTyr143) antibody
H2AFX 适用: 人, 小鼠, 大鼠 ELISA, IHC (p), ICC, FACS, IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-H2A Histone Family, Member X (H2AFX) (pSer139) antibody
H2AFX 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Monoclonal 1C14 unconjugated

应用备注

Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
Immunofluorescence: 1:100-1:200

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C/-20 °C

储存方法

Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Qing, Liang, Du, Fan, Xu, Xu, Shi: "Apoptosis induced by trimethyltin chloride in human neuroblastoma cells SY5Y is regulated by a balance and cross-talk between NF-κB and MAPKs signaling pathways." in: Archives of toxicology, Vol. 87, Issue 7, pp. 1273-85, (2013) (PubMed).

Li, Hu, He, Li, Zhu, Hou, Zhang, Li, Zhang, Wang, Liu, Yao, Zhang: "Up-regulation of NDRG2 through nuclear factor-kappa B is required for Leydig cell apoptosis in both human and murine infertile testes." in: Biochimica et biophysica acta, Vol. 1822, Issue 2, pp. 301-13, (2012) (PubMed).

Li, Kikuchi, Zheng, Noguchi, Takahashi, Nishida, Masuda, Yang, Takano: "Downregulation and translocation of nuclear ING4 is correlated with tumorigenesis and progression of head and neck squamous cell carcinoma." in: Oral oncology, Vol. 47, Issue 3, pp. 217-23, (2011) (PubMed).

Li, Nishida, Noguchi, Zheng, Takahashi, Yang, Masuda, Takano: "Decreased nuclear expression and increased cytoplasmic expression of ING5 may be linked to tumorigenesis and progression in human head and neck squamous cell carcinoma." in: Journal of cancer research and clinical oncology, Vol. 136, Issue 10, pp. 1573-83, (2010) (PubMed).

Dickey, Redon, Nakamura, Baird, Sedelnikova, Bonner: "H2AX: functional roles and potential applications." in: Chromosoma, Vol. 118, Issue 6, pp. 683-92, (2009) (PubMed).
抗原

H2AFX (H2A Histone Family, Member X (H2AFX))

别名

Histone H2A.X

背景

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation

分子量

15 kDa

NCBI登录号

NP_002096

UniProt

P16104

途径

Telomere Maintenance, DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus