Bcl-2 抗体 (AA 68-72)
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Quick Overview for Bcl-2 抗体 (AA 68-72) (ABIN362595)
抗原
See all Bcl-2 (BCL2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 68-72
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特异性
- The antibody detects endogenous level of total BCL-2 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
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免疫原
- Peptide sequence around AA 68-72 (R-T-S-P-L) derived from Human BCL-2. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
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亚型
- IgG
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应用备注
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Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
Immunofluorescence: 1:100-1:200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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: "Lentivirus-mediated Sirt1 shRNA and resveratrol independently induce porcine preadipocyte apoptosis by canonical apoptotic pathway." in: Molecular biology reports, Vol. 40, Issue 1, pp. 129-39, (2012) (PubMed).
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- Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
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别名
- BCL-2
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背景
- BCL-2 encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. Muller IM, et al. (2005) Mol Pharmacol.
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分子量
- 26 kDa
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NCBI登录号
- NP_000624
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UniProt
- P10415
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途径
- MAPK Pathway, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
抗原
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