RELB 抗体 (pSer573)
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- 抗原 See all RELB 抗体
- RELB (V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB))
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抗原表位
- pSer573
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RELB antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 特异性
- The antibody detects endogenous level of RelB only when phosphorylated at serine 573.
- 纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
- 免疫原
- Peptide sequence around phosphorylation site of pSer573 (L-L-S (p) -P-G) derived from Human RelB. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
- 亚型
- IgG
- Top Product
- Discover our top product RELB Primary Antibody
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anti-V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB) (AA 1-579) antibody
RELB 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB) (AA 1-579) antibodyRELB 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB) (C-Term) antibodyRELB 适用: 人, 小鼠 WB, IP, IHC (p), ChIP 宿主: 兔 Polyclonal unconjugated
anti-V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB) (pSer573) antibodyRELB 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB) (AA 248-492) antibodyRELB 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB) (AA 161-260) antibodyRELB 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), FACS, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB) antibodyRELB 适用: 人, 小鼠 WB 宿主: 小鼠 Monoclonal 4C5 unconjugated
anti-V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB) (AA 400-579) antibodyRELB 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB) (pSer573) antibodyRELB 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB) antibodyRELB 适用: 人, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- 抗原
- RELB (V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB))
- 别名
- RelB (RELB 产品)
- 别名
- shep antibody, I-REL antibody, IREL antibody, REL-B antibody, XRelB antibody, relb-A antibody, GC-rich antibody, avian reticuloendotheliosis viral (v-rel) oncogene related B antibody, RELB proto-oncogene, NF-kB subunit antibody, v-rel avian reticuloendotheliosis viral oncogene homolog B S homeolog antibody, Relb antibody, RELB antibody, relb.S antibody
- 背景
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NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.
NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. - 分子量
- 70 kDa
- NCBI登录号
- NP_006500
- UniProt
- Q01201
- 途径
- NF-kappaB Signaling, RTK signaling
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