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ATM 抗体 (pSer1981)

There are 4+ publications for this product available. The 兔多克隆 anti-ATM antibody is suitable to detect ATM in samples from 人和小鼠. It has been validated for IHC.

(4 references)

产品编号 ABIN362099

发货至: 中国

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Quick Overview for ATM 抗体 (pSer1981) (ABIN362099)

抗原

See all ATM 抗体

ATM (Ataxia Telangiectasia Mutated (ATM))

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This ATM antibody is un-conjugated

应用范围

Immunohistochemistry (IHC)

Discover our top product ATM Primary Antibody

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pSer1981

特异性

The antibody detects endogenous level of ATM only when phosphorylated at serine 1981.

纯化方法

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.

免疫原

Peptide sequence around phosphorylation site of pSer1981 (E-G-S (p) -Q-S) derived from Human ATM. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

亚型

IgG
anti-Ataxia Telangiectasia Mutated (ATM) (AA 1974-1988), (pSer1981) antibody
ATM 适用: 人 WB, IHC, ELISA, IF, IP, FACS, FM 宿主: 小鼠 Monoclonal 10H11-E12 unconjugated

anti-Ataxia Telangiectasia Mutated (ATM) (AA 1974-1988), (pSer1981) antibody
ATM 适用: 人 WB, IHC, ELISA, IF, IP, FACS, FM 宿主: 小鼠 Monoclonal 10H11-E12 unconjugated

anti-Ataxia Telangiectasia Mutated (ATM) (C-Term) antibody
ATM 适用: 人, 小鼠 WB, IHC, ELISA, IF, IP, ICC, FACS 宿主: 兔 Polyclonal unconjugated

anti-Ataxia Telangiectasia Mutated (ATM) (AA 2681-2750) antibody
ATM 适用: 人, 小鼠 WB, ELISA, IHC (p), FACS, IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Ataxia Telangiectasia Mutated (ATM) (AA 2484-2748) antibody
ATM 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Ataxia Telangiectasia Mutated (ATM) antibody
ATM 适用: 人 WB, IHC, ELISA, IP 宿主: 兔 Monoclonal 4E11 unconjugated Recombinant Antibody

anti-Ataxia Telangiectasia Mutated (ATM) (AA 1974-1988), (pSer1981) antibody (HRP)
ATM 适用: 人 WB, IHC, ELISA, FM 宿主: 小鼠 Monoclonal 10H11-E12 HRP

anti-Ataxia Telangiectasia Mutated (ATM) (AA 1974-1988), (pSer1981) antibody
ATM 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 7C10D8 unconjugated

anti-Ataxia Telangiectasia Mutated (ATM) (AA 486-742) antibody
ATM 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Ataxia Telangiectasia Mutated (ATM) antibody
KO Validated ATM 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB530 unconjugated Recombinant Antibody

应用备注

Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C/-20 °C

储存方法

Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Inaba, Kuboniwa, Sugita, Lamont, Amano: "Identification of signaling pathways mediating cell cycle arrest and apoptosis induced by Porphyromonas gingivalis in human trophoblasts." in: Infection and immunity, Vol. 80, Issue 8, pp. 2847-57, (2012) (PubMed).

Mahalingam, Tay, Tan, Chai, Wang: "Mutant telomerase RNAs induce DNA damage and apoptosis via the TRF2-ATM pathway in telomerase-overexpressing primary fibroblasts." in: The FEBS journal, Vol. 278, Issue 19, pp. 3724-38, (2011) (PubMed).

Leemput, Masson, Bigot, Errachid, Dansault, Provost, Gadin, Aoufouchi, Menasche, Abitbol: "ATM localization and gene expression in the adult mouse eye." in: Molecular vision, Vol. 15, pp. 393-416, (2009) (PubMed).

Kang, Guo, Tan, Zhao, Tang, Lu: "Expression status of ataxia-telangiectasia-mutated gene correlated with prognosis in advanced gastric cancer." in: Mutation research, Vol. 638, Issue 1-2, pp. 17-25, (2008) (PubMed).
抗原

ATM (Ataxia Telangiectasia Mutated (ATM))

别名

ATM

背景

ATM encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene.

分子量

350 kDa

NCBI登录号

NP_000042

UniProt

Q13315

途径

p53 Pathway, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus