The antibody detects endogenous level of PKD/PKCm only when phosphorylated at serine 910.
纯化方法
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.
免疫原
Peptide sequence around phosphorylation site of pSer910 (R-V-S (p) -I-L) derived from Human PKD, PKCm. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
Converts transient diacylglycerol. (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress through activation of NF-kappa-B.