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Nibrin 抗体 (pSer343)

NBN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN361984
发货至: 中国
  • 抗原 See all Nibrin (NBN) 抗体
    Nibrin (NBN)
    抗原表位
    • 37
    • 15
    • 12
    • 8
    • 7
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer343
    适用
    • 102
    • 62
    • 36
    • 2
    • 1
    • 1
    • 1
    • 1
    宿主
    • 121
    • 15
    克隆类型
    • 109
    • 27
    多克隆
    标记
    • 70
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This Nibrin antibody is un-conjugated
    应用范围
    • 107
    • 45
    • 30
    • 27
    • 26
    • 26
    • 26
    • 18
    • 12
    • 11
    • 6
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB)
    特异性
    The antibody detects endogenous level of p95/NBS1 only when phosphorylated at serine 343.
    纯化方法
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
    免疫原
    Peptide sequence around phosphorylation site of pSer343 (S-L-S (p) -Q-G) derived from Human p95, NBS1. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
    亚型
    IgG
    Top Product
    Discover our top product NBN Primary Antibody
  • 应用备注
    Western blotting: 1:500-1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Drissi, Wu, Hu, Bockhold, Dome: "Telomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells." in: Cancer prevention research (Philadelphia, Pa.), Vol. 4, Issue 12, pp. 1973-81, (2011) (PubMed).

    Carrillo, Schneider, Taylor, Srinivasan, Kapoor, Bhatia: "Prominent oromandibular dystonia and pharyngeal telangiectasia in atypical ataxia telangiectasia." in: Cerebellum (London, England), Vol. 8, Issue 1, pp. 22-7, (2009) (PubMed).

  • 抗原
    Nibrin (NBN)
    别名
    p95/NBS1 (NBN 产品)
    别名
    NBN antibody, AT-V1 antibody, AT-V2 antibody, ATV antibody, NBS antibody, NBS1 antibody, P95 antibody, Nbs1 antibody, im:6911679 antibody, zgc:194152 antibody, nibrin antibody, NBN antibody, nbn antibody, Nbn antibody
    背景
    Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
    分子量
    95 kDa
    NCBI登录号
    NP_002476
    UniProt
    O60934
    途径
    DNA Damage Repair, Production of Molecular Mediator of Immune Response
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