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Nibrin 抗体 (pSer343)

Cited in 2+ publications. The 兔多克隆 anti-Nibrin antibody (ABIN361984) specifically detects Nibrin in WB. The antibody is reactive with 人 samples.

(2 references)

产品编号 ABIN361984

发货至: 中国

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Quick Overview for Nibrin 抗体 (pSer343) (ABIN361984)

抗原

See all Nibrin (NBN) 抗体

Nibrin (NBN)

适用

人

宿主

兔

克隆类型

多克隆

标记

This Nibrin antibody is un-conjugated

应用范围

Western Blotting (WB)

Discover our top product NBN Primary Antibody

抗原表位
49

15

10

8

5

4

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer343

特异性

The antibody detects endogenous level of p95/NBS1 only when phosphorylated at serine 343.

纯化方法

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.

免疫原

Peptide sequence around phosphorylation site of pSer343 (S-L-S (p) -Q-G) derived from Human p95, NBS1. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

亚型

IgG
anti-Nibrin (NBN) (AA 467-615) antibody
NBN 适用: 人 WB, IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 7E4C2 unconjugated

anti-Nibrin (NBN) (AA 467-615) antibody
NBN 适用: 人, 大鼠 WB, IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 7E4A2 unconjugated

anti-Nibrin (NBN) (AA 461-754) antibody
NBN 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 3A9 unconjugated

anti-Nibrin (NBN) (AA 461-754) antibody
NBN 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 3A2 unconjugated

anti-Nibrin (NBN) (AA 183-460) antibody
NBN 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 6E11 unconjugated

anti-Nibrin (NBN) (AA 183-460) antibody
NBN 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2F5 unconjugated

anti-Nibrin (NBN) (AA 183-460) antibody
NBN 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 8E7 unconjugated

anti-Nibrin (NBN) (AA 435-754) antibody
NBN 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Nibrin (NBN) (AA 714-745), (C-Term) antibody
NBN 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Nibrin (NBN) antibody
KO Validated NBN 适用: 人 WB, IF, ICC, IP 宿主: 兔 Polyclonal unconjugated

应用备注

Western blotting: 1:500-1:1000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C/-20 °C

储存方法

Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Drissi, Wu, Hu, Bockhold, Dome: "Telomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells." in: Cancer prevention research (Philadelphia, Pa.), Vol. 4, Issue 12, pp. 1973-81, (2011) (PubMed).

Carrillo, Schneider, Taylor, Srinivasan, Kapoor, Bhatia: "Prominent oromandibular dystonia and pharyngeal telangiectasia in atypical ataxia telangiectasia." in: Cerebellum (London, England), Vol. 8, Issue 1, pp. 22-7, (2009) (PubMed).
抗原

Nibrin (NBN)

别名

p95/NBS1

背景

Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

分子量

95 kDa

NCBI登录号

NP_002476

UniProt

O60934

途径

DNA Damage Repair, Production of Molecular Mediator of Immune Response