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c-MET 抗体 (pTyr1234, pTyr1235)

Name: c-MET 抗体 (pTyr1234, pTyr1235)
SKU: ABIN356338
Availability: OutOfStock

MET 适用: 人, 小鼠 WB, EIA 宿主: 小鼠 Monoclonal 6AT1877 unconjugated

Western Blotting (WB) image for anti-Met Proto-Oncogene (MET) (pTyr1234), (pTyr1235) antibody (ABIN356338)

1 image

产品编号 ABIN356338

发货至: 中国

Datasheet as PDF

抗原 See all c-MET (MET) 抗体

c-MET (MET) (Met Proto-Oncogene (MET))
抗原表位
48

34

28

21

16

12

11

8

7

7

7

6

5

5

4

4

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pTyr1234, pTyr1235
适用
250

143

98

8

6

4

4

4

2

2

2

1

1

1

1
人, 小鼠
宿主
222

38

3

2
小鼠
Compatible Secondaries
克隆类型
210

55
单克隆
标记
131

20

13

12

9

9

9

9

9

9

8

7

3

3

3

3

3

1

1

1

1

1
This c-MET antibody is un-conjugated
应用范围
181

105

51

43

31

27

26

24

15

8

8

7

4

3

1

1

1
Western Blotting (WB), Enzyme Immunoassay (EIA)

特异性

This antibody detects MET/HGFR pTyr1234/1235.

交叉反应（详细）

Species reactivity (tested):Human and Mouse.

产品特性

Synonyms: Hepatocyte growth factor receptor, MET, Scatter factor receptor, HGF/SF receptor, c-Met,Met proto-oncogene tyrosine kinase

纯化方法

Protein G Chromatography eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

免疫原

This monoclonal antibody is generated from mice immunized with a KLH conjugatedsynthetic peptide corresponding to sequences in Tyr1234/1235 region of human Met andresidues both Tyr1234 and Tyr1235 are phosphorylated.

克隆位点

6AT1877

亚型

IgG1

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应用备注

ELISA: 1/1,000. Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
状态

Liquid

浓度

0.25 mg/mL

缓冲液

PBS with 0.09 % (W/V) Sodium Azide as preservative, 0.09 % (W/V) Sodium Azide

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C/-20 °C

储存方法

Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

有效期

12 months
抗原

c-MET (MET) (Met Proto-Oncogene (MET))

别名

HGF Receptor (MET 产品)

别名

AUTS9 antibody, HGFR antibody, RCCP2 antibody, c-Met antibody, AI838057 antibody, HGF antibody, Par4 antibody, Hgfr antibody, c-met antibody, MET antibody, C-MET antibody, met antibody, met-A antibody, MET proto-oncogene, receptor tyrosine kinase antibody, met proto-oncogene antibody, MET proto-oncogene, receptor tyrosine kinase L homeolog antibody, MET antibody, Met antibody, met.L antibody

背景

MET/HGFR is a receptor for hepatocyte growth factor, with tyrosine-protein kinase activity. The MET/HGFR Type I membrane protein contains 1 Sema domain and consists of a heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. In the fully processed c-Met product, the alpha subunit is extracellular, and the beta subunit has extracellular, transmembrane, and tyrosine kinase domains as well as sites of tyrosine phosphorylation. Two isoforms for the protein have been described. Activation of MET after rearrangement with the TPR gene produces an oncogenic protein. MET is overexpressed in a significant percentage of human cancers and is amplified during the transition between primary tumors and metastasis. Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC), also known as papillary renal cell carcinoma 2 (RCCP2). HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance.Synonyms: HGF/SF receptor, Hepatocyte growth factor receptor, MET, Met proto-oncogene tyrosine kinase, Scatter factor receptor, c-Met

基因ID

4233

UniProt

P08581

途径

RTK signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor