LBP 抗体
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北京 101111
Quick Overview for LBP 抗体 (ABIN343177)
抗原
See all LBP 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- Protein G purified
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免疫原
- LBP knock out mouse immunized with immunoaffinity purified recombinant human LBP
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亚型
- IgG1
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anti-Lipopolysaccharide Binding Protein (LBP) (AA 226-480) antibody
LBP 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lipopolysaccharide Binding Protein (LBP) (AA 224-468) antibodyLBP 适用: Cow WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lipopolysaccharide Binding Protein (LBP) (AA 25-481) antibodyLBP 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lipopolysaccharide Binding Protein (LBP) antibodyLBP 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Lipopolysaccharide Binding Protein (LBP) (AA 27-481) antibodyLBP 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lipopolysaccharide Binding Protein (LBP) (AA 27-481) antibodyLBP 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Lipopolysaccharide Binding Protein (LBP) (AA 27-481) antibodyLBP 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lipopolysaccharide Binding Protein (LBP) antibodyLBP 适用: 人 IHC (p) 宿主: 小鼠 Monoclonal biG42 unconjugated
anti-Lipopolysaccharide Binding Protein (LBP) antibodyLBP 适用: 小鼠 ELISA 宿主: 小鼠 Monoclonal biG35 unconjugated
anti-Lipopolysaccharide Binding Protein (LBP) antibodyLBP 适用: 小鼠 ELISA 宿主: 小鼠 Monoclonal biG33 unconjugated
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应用备注
- inhibition of LPS binding to membrane bound CD14, inhibition titre 1:1000. Binding titre at human LBP- ELISA: 1:50.000, cross reacting with bovine LBP.
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限制
- 仅限研究用
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状态
- Lyophilized
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浓度
- 2.0 mg/ml (determined by mouse IgG-ELISA) before lyophilization
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缓冲液
- with NaN3
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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: "Role of the lipopolysaccharide-CD14 complex for the activity of hemolysin from uropathogenic Escherichia coli." in: Infection and immunity, Vol. 75, Issue 2, pp. 997-1004, (2007) (PubMed).
: "Lipopolysaccharide-binding protein critically regulates lipopolysaccharide-induced IFN-beta signaling pathway in human monocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 10, pp. 6185-94, (2004) (PubMed).
: "Elevated levels of lipopolysaccharide-binding protein and soluble CD14 in plasma in neonatal early-onset sepsis." in: Clinical and diagnostic laboratory immunology, Vol. 9, Issue 2, pp. 440-5, (2002) (PubMed).
: "Soluble CD14 in human breast milk and its role in innate immune responses." in: Acta odontologica Scandinavica, Vol. 59, Issue 5, pp. 330-4, (2001) (PubMed).
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: "Role of the lipopolysaccharide-CD14 complex for the activity of hemolysin from uropathogenic Escherichia coli." in: Infection and immunity, Vol. 75, Issue 2, pp. 997-1004, (2007) (PubMed).
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- LBP (Lipopolysaccharide Binding Protein (LBP))
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别名
- Lipopolysaccharide (LPS)-Binding Protein (LBP)
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背景
- LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to a 100-1,000-fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria
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途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process
抗原
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