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LBP 抗体

LBP 适用: 人 IHC (p) 宿主: 小鼠 Monoclonal biG42 unconjugated
产品编号 ABIN343175
发货至: 中国
  • 抗原 See all LBP 抗体
    LBP (Lipopolysaccharide Binding Protein (LBP))
    适用
    • 38
    • 20
    • 17
    • 9
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    • 6
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    宿主
    • 45
    • 18
    • 5
    • 2
    小鼠
    克隆类型
    • 47
    • 23
    单克隆
    标记
    • 56
    • 7
    • 3
    • 3
    • 1
    This LBP antibody is un-conjugated
    应用范围
    • 47
    • 28
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    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    特异性
    Human LBP (Lipopolysaccaride binding protein). The antibody don't block LPS binding to membrane bound CD14.
    交叉反应
    牛, 犬, 马, 兔
    纯化方法
    Protein A affinity column
    免疫原
    native human LBP
    克隆位点
    BiG42
    亚型
    IgG1
    Top Product
    Discover our top product LBP Primary Antibody
  • 应用备注
    ELISA, Immune histology at paraffin sections, LBP inhibition studies, Western Blot. No inhibition of LPS binding to membrane bound CD14 Binding titre at human LBP- ELISA: 1:10.000
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Reconstitute with bidistilled water
    浓度
    1 mg/mL
    缓冲液
    PBS, pH 7.12
    储存液
    Without preservative
    储存条件
    -20 °C,-80 °C
  • Eckert, Kim, Kim, Gürtler, Oh, Sur, Lundvall, Hamann, van der Ploeg, Pickkers, Giamarellos-Bourboulis, Kubarenko, Weber, Kabesch, Kumpf, An, Lee, Schumann: "The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity." in: Immunity, Vol. 39, Issue 4, pp. 647-60, (2013) (PubMed).

    Rahman, Lecchi, Avallone, Roccabianca, Sartorelli, Ceciliani: "Lipopolysaccharide-binding protein: Local expression in bovine extrahepatic tissues." in: Veterinary immunology and immunopathology, (2010) (PubMed).

    Ren, Jin, Leung: "Local expression of lipopolysaccharide-binding protein in human gingival tissues." in: Journal of periodontal research, Vol. 39, Issue 4, pp. 242-8, (2004) (PubMed).

  • 抗原
    LBP (Lipopolysaccharide Binding Protein (LBP))
    别名
    Lipopolysaccharide (LPS)-Binding Protein (LBP) (LBP 产品)
    别名
    BPIFD2 antibody, Bpifd2 antibody, Ly88 antibody, LPSBP antibody, LBP antibody, lipopolysaccharide binding protein antibody, lipopolysaccharide-binding protein antibody, LBP antibody, Lbp antibody, LOC100472839 antibody
    背景
    Background: Natural Lipopolysccaride Binding Protein (LBP) is a 58KD glycoprotein produced in liver. It binds at lipid A of LPS with high affinity (10-9M) and reduced the cellular LPS effects at CD14+ cells (IL1ß, IL6, TNFα). It acts as opsonin for GRAM negative cells, LPS, neutrophiles and granulocytes.
    分子量
    ~58kDa
    基因ID
    3929
    NCBI登录号
    NP_004130
    UniProt
    P18428
    途径
    TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process
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