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LBP 抗体

LBP 适用: 小鼠 ELISA 宿主: 小鼠 Monoclonal biG33 unconjugated
产品编号 ABIN343173
发货至: 中国
  • 抗原 See all LBP 抗体
    LBP (Lipopolysaccharide Binding Protein (LBP))
    适用
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    小鼠
    宿主
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    小鼠
    克隆类型
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    单克隆
    标记
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    This LBP antibody is un-conjugated
    应用范围
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    ELISA
    特异性
    Mouse LBP. The antibody blocks LPS binding to membrane bound CD14.
    交叉反应
    人, 大鼠
    纯化方法
    Protein G affinity column
    免疫原
    native mouse LBP
    克隆位点
    BiG33
    亚型
    IgG1
    Top Product
    Discover our top product LBP Primary Antibody
  • 应用备注
    ELISA ,LBP inhibition studies, Western Blot. inhibits binding of LPS to membrane bound CD14, (Inhibits LPS-binding (0.5 ug/ml) to CD14+CHO cells (2 x 106/ml) up to 1:1000, total inhibition 1:5 Binding titre at mouse LBP- ELISA: 1:50.000 Cross reacting with rat LBP
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Reconstitute with bidistilled water
    浓度
    1 mg/mL
    缓冲液
    PBS, pH 7.17
    储存液
    Without preservative
    储存条件
    -20 °C,-80 °C
  • Dziarski, Tapping, Tobias: "Binding of bacterial peptidoglycan to CD14." in: The Journal of biological chemistry, Vol. 273, Issue 15, pp. 8680-90, (1998) (PubMed).

    Weidemann, Schletter, Dziarski, Kusumoto, Stelter, Rietschel, Flad, Ulmer: "Specific binding of soluble peptidoglycan and muramyldipeptide to CD14 on human monocytes." in: Infection and immunity, Vol. 65, Issue 3, pp. 858-64, (1997) (PubMed).

  • 抗原
    LBP (Lipopolysaccharide Binding Protein (LBP))
    别名
    Lipopolysaccharide (LPS)-Binding Protein (LBP) (LBP 产品)
    别名
    BPIFD2 antibody, Bpifd2 antibody, Ly88 antibody, LPSBP antibody, LBP antibody, lipopolysaccharide binding protein antibody, lipopolysaccharide-binding protein antibody, LBP antibody, Lbp antibody, LOC100472839 antibody
    背景
    Background: Natural LBP is a 58KD glycoprotein produced in liver. It binds at lipid A of LPS with high affinity (10-9M) and reduced the cellular LPS effects at CD14+ cells (IL1ß, IL6, TNFα). It acts as opsonin for GRAM negative cells, LPS, neutrophiles and granulocytes.
    分子量
    ~58kDa
    基因ID
    16803
    UniProt
    Q61805
    途径
    TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process
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