CD14 抗体 (AA 147-152)
Quick Overview for CD14 抗体 (AA 147-152) (ABIN343170)
抗原
See all CD14 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 147-152
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特异性
- Soluble and membrane bound human CD14. The antibody does'nt significant block LPS binding to membrane bound CD14.
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纯化方法
- Protein G affinity column
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免疫原
- human Monocytes
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亚型
- IgG1
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应用备注
- no significant inhibition of LPS binding to CD14
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstitute with bidistilled water
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浓度
- 1 mg/mL
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缓冲液
- PBS, pH 7.7
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储存液
- Without preservative
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储存条件
- -20 °C,-80 °C
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Differential impact of substitution of amino acids 9-13 and 91-101 of human CD14 on soluble CD14-dependent activation of cells by lipopolysaccharide." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 11, pp. 6035-44, (1999) (PubMed).
: "Binding of bacterial peptidoglycan to CD14." in: The Journal of biological chemistry, Vol. 273, Issue 15, pp. 8680-90, (1998) (PubMed).
: "Low endotoxic potential of Legionella pneumophila lipopolysaccharide due to failure of interaction with the monocyte lipopolysaccharide receptor CD14." in: Infection and immunity, Vol. 66, Issue 9, pp. 4151-7, (1998) (PubMed).
: "
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Differential impact of substitution of amino acids 9-13 and 91-101 of human CD14 on soluble CD14-dependent activation of cells by lipopolysaccharide." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 11, pp. 6035-44, (1999) (PubMed).
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- CD14
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别名
- CD14
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背景
- Background: biG 2 represents an excellent marker for CD14. The CD14 glycoprotein, gp 55, is present on most monocytic and macrophages like cell types: monocytes, macrophages, weekly at surface of neutrophiles like Kupffer cells, pleural phagocytic cells and dendritic reticular cells. CD14 is also observed on granulocytes and activated or transformed B-cells. Furthermore CD14 is present in a soluble form in human serum, urine and other body fluids. The CD14 Molecule has been reported to be a receptor for endotoxin. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a high affinity receptor for LPS-LBP (lipopolysaccharide binding protein)-complexes.
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分子量
- ~50kDa
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基因ID
- 929
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NCBI登录号
- NP_000582
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UniProt
- P08571
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途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
抗原
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