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CD14 抗体 (AA 147-152)

This anti-CD14 antibody is a 小鼠 单克隆 antibody detecting CD14 in FACS, IF 和 Agon. Suitable for 人. This Primary Antibody has been cited in 3+ publications.
产品编号 ABIN343170
发货至: 中国

Quick Overview for CD14 抗体 (AA 147-152) (ABIN343170)

抗原

See all CD14 抗体
CD14

适用

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宿主

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小鼠

克隆类型

  • 296
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单克隆

标记

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This CD14 antibody is un-conjugated

应用范围

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Flow Cytometry (FACS), Immunofluorescence (IF), Agonist (Agon)

克隆位点

BiG2
  • 抗原表位

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    AA 147-152

    特异性

    Soluble and membrane bound human CD14. The antibody does'nt significant block LPS binding to membrane bound CD14.

    纯化方法

    Protein G affinity column

    免疫原

    human Monocytes

    亚型

    IgG1
  • 应用备注

    no significant inhibition of LPS binding to CD14

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Reconstitute with bidistilled water

    浓度

    1 mg/mL

    缓冲液

    PBS, pH 7.7

    储存液

    Without preservative

    储存条件

    -20 °C,-80 °C
  • Stelter, Loppnow, Menzel, Grunwald, Bernheiden, Jack, Ulmer, Schuett: "Differential impact of substitution of amino acids 9-13 and 91-101 of human CD14 on soluble CD14-dependent activation of cells by lipopolysaccharide." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 11, pp. 6035-44, (1999) (PubMed).

    Dziarski, Tapping, Tobias: "Binding of bacterial peptidoglycan to CD14." in: The Journal of biological chemistry, Vol. 273, Issue 15, pp. 8680-90, (1998) (PubMed).

    Neumeister, Faigle, Sommer, Zaehringer, Stelter, Menzel, Schuett, Northoff: "Low endotoxic potential of Legionella pneumophila lipopolysaccharide due to failure of interaction with the monocyte lipopolysaccharide receptor CD14." in: Infection and immunity, Vol. 66, Issue 9, pp. 4151-7, (1998) (PubMed).

  • 抗原

    CD14

    别名

    CD14

    背景

    Background: biG 2 represents an excellent marker for CD14. The CD14 glycoprotein, gp 55, is present on most monocytic and macrophages like cell types: monocytes, macrophages, weekly at surface of neutrophiles like Kupffer cells, pleural phagocytic cells and dendritic reticular cells. CD14 is also observed on granulocytes and activated or transformed B-cells. Furthermore CD14 is present in a soluble form in human serum, urine and other body fluids. The CD14 Molecule has been reported to be a receptor for endotoxin. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a high affinity receptor for LPS-LBP (lipopolysaccharide binding protein)-complexes.

    分子量

    ~50kDa

    基因ID

    929

    NCBI登录号

    NP_000582

    UniProt

    P08571

    途径

    TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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