Retinoblastoma 1 抗体 (pThr821)
(4 references)-
- 抗原 See all Retinoblastoma 1 (RB1) 抗体
- Retinoblastoma 1 (RB1)
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抗原表位
- pThr821
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Retinoblastoma 1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- Specific to human Rb phosphorylated at Thr821.
- 交叉反应 （详细）
- Not tested for other species. Can detect endogenous levels of Rb phosphorylated at Thr821 in most cell lines.
- 纯化方法
- Purified
- 过滤
- Sterile filtered
- 免疫原
- A synthetic peptide containing pThr821 of human Rb
- 克隆位点
- 24A7
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product RB1 Primary Antibody
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anti-Retinoblastoma 1 (RB1) (C-Term) antibody
RB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma 1 (RB1) (pSer795) antibodyRB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma 1 (RB1) (pSer807) antibodyRB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma 1 (RB1) (pSer780) antibodyRB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma 1 (RB1) (pSer612) antibodyRB1 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 3C11 unconjugated
anti-Retinoblastoma 1 (RB1) (pSer807) antibodyRB1 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 5H12 unconjugated
anti-Retinoblastoma 1 (RB1) (C-Term) antibodyRB1 适用: 人 WB, IF, IP, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma 1 (RB1) (pSer807), (pSer811) antibodyRB1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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1. Western blotting: ~1 g/mL
2. ELISA
Other applications were not tested. - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS, 50 % glycerol
- 储存液
- Azide free
- 储存条件
- -20 °C
- 储存方法
- Store at -20 C (For long term storage: -70 C).
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: "Cancer cell cycles." in: Science (New York, N.Y.), Vol. 274, Issue 5293, pp. 1672-7, (1997) (PubMed).
: "A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle." in: Cell, Vol. 75, Issue 4, pp. 779-90, (1993) (PubMed).
: "E2F: a link between the Rb tumor suppressor protein and viral oncoproteins." in: Science (New York, N.Y.), Vol. 258, Issue 5081, pp. 424-9, (1992) (PubMed).
: "The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations." in: The EMBO journal, Vol. 9, Issue 4, pp. 1147-55, (1990) (PubMed).
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: "Cancer cell cycles." in: Science (New York, N.Y.), Vol. 274, Issue 5293, pp. 1672-7, (1997) (PubMed).
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- 抗原
- Retinoblastoma 1 (RB1)
- 别名
- RB (RB1 产品)
- 别名
- OSRC antibody, RB antibody, p105-Rb antibody, pRb antibody, pp110 antibody, Rb antibody, Rb-1 antibody, P105-RB antibody, PP110 antibody, RB11 antibody, zgc:154147 antibody, RB transcriptional corepressor 1 antibody, RB transcriptional corepressor like 1 antibody, retinoblastoma 1 antibody, RB1 antibody, RBL1 antibody, Rb1 antibody, rb1 antibody
- 背景
- Retinoblastoma protein (Rb), the tumor suppressor product of the retinoblastoma susceptibility gene, is a 110 kDa protein that functions as a negative regulator of the cell cycle by arresting cells in the G1 phase and halting inappropriate cell proliferation. At the transcriptional level, Rb protein exerts its growth suppressive function by binding to transcription factors including E2F1, PU1, ATF2, UBF, Elf-1 and c-Abl. Loss of Rb function leads to uncontrolled cell growth and tumor development and is found in all retinoblastomas and in a variety of other human malignancies. The ability of Rb protein to inhinbit transcription and cell cycle progression is inactivated by hosphorylation, which is catalyzed by the cyclin-dependent protein kinases.
- UniProt
- P06400
- 途径
- Cell Division Cycle, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagy
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