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Retinoblastoma 1 抗体 (AA 586-615)

Name: Retinoblastoma 1 抗体 (AA 586-615)
SKU: ABIN1881730
Availability: OutOfStock

RB1 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB7977 unconjugated

Rb Antibody (ABIN1881730 and ABIN2840685) western blot analysis in Daudi,Raji cell line lysates (35 μg/lane). (Retinoblastoma 1 抗体 (AA 586-615))

RB1 Antibody (ABIN1881730 and ABIN2840685) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. (Retinoblastoma 1 抗体 (AA 586-615))

IHC (p)

Confocal immunofluorescent analysis of RB1 Antibody (ABIN1881730 and ABIN2840685) with MDA-M cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (Retinoblastoma 1 抗体 (AA 586-615))

3 images

(4 references)

产品编号 ABIN1881730

发货至: 中国

Datasheet as PDF

抗原 See all Retinoblastoma 1 (RB1) 抗体

Retinoblastoma 1 (RB1)
抗原表位
32

31

29

24

24

22

20

15

11

10

10

7

6

6

4

3

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 586-615
适用
290

113

95

5

4

4

3

3

3

2

1

1

1
人
宿主
251

42
兔
Compatible Secondaries
克隆类型
237

56
多克隆
标记
146

19

17

16

11

11

6

6

6

6

6

6

6

6

6

6

6

1

1

1

1

1

1

1
This Retinoblastoma 1 antibody is un-conjugated
应用范围
222

132

114

80

79

41

39

34

28

19

19

9

8

6

6

2

2
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This RB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-615 amino acids from human RB1.

克隆位点

RB7977

亚型

Ig Fraction

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anti-Retinoblastoma 1 (RB1) (pSer780) antibody
RB1 适用: 人, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma 1 (RB1) (pSer795) antibody
RB1 适用: 人 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma 1 (RB1) (C-Term) antibody
RB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma 1 (RB1) (pSer795) antibody
RB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma 1 (RB1) (pSer807) antibody
RB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma 1 (RB1) (pSer780) antibody
RB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma 1 (RB1) (pSer612) antibody
RB1 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 3C11 unconjugated

anti-Retinoblastoma 1 (RB1) (pSer807) antibody
RB1 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 5H12 unconjugated

anti-Retinoblastoma 1 (RB1) (C-Term) antibody
RB1 适用: 人 WB, IF, IP, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma 1 (RB1) (pSer780) antibody
RB1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated

应用备注

IF: 1:10~50. WB: 1:1000. IHC-P: 1:10~50

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Dasgupta, Sun, Wang, Fusaro, Betts, Padmanabhan, Sebti, Chellappan: "Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis." in: Molecular and cellular biology, Vol. 24, Issue 21, pp. 9527-41, (2004) (PubMed).

Cui, Shirai, Wakai, Yokoyama, Hirano, Hatakeyama: "Aberrant expression of pRb and p16(INK4), alone or in combination, indicates poor outcome after resection in patients with colorectal carcinoma." in: Human pathology, Vol. 35, Issue 10, pp. 1189-95, (2004) (PubMed).

Borah, Verma, Robertson: "ORF73 of herpesvirus saimiri, a viral homolog of Kaposi's sarcoma-associated herpesvirus, modulates the two cellular tumor suppressor proteins p53 and pRb." in: Journal of virology, Vol. 78, Issue 19, pp. 10336-47, (2004) (PubMed).

Dasgupta, Betts, Rastogi, Joshi, Morris, Brennan, Ordonez-Ercan, Chellappan: "Direct binding of apoptosis signal-regulating kinase 1 to retinoblastoma protein: novel links between apoptotic signaling and cell cycle machinery." in: The Journal of biological chemistry, Vol. 279, Issue 37, pp. 38762-9, (2004) (PubMed).
抗原

Retinoblastoma 1 (RB1)

别名

RB1 (RB1 产品)

别名

OSRC antibody, RB antibody, p105-Rb antibody, pRb antibody, pp110 antibody, Rb antibody, Rb-1 antibody, P105-RB antibody, PP110 antibody, RB11 antibody, zgc:154147 antibody, RB transcriptional corepressor 1 antibody, RB transcriptional corepressor like 1 antibody, retinoblastoma 1 antibody, RB1 antibody, RBL1 antibody, Rb1 antibody, rb1 antibody

背景

The retinoblastoma protein is a tumor suppressor protein that is dysfunctional in many types of cancer.[1] One highly studied function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. pRb belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins.[2][3] Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomaviruses, bind and inactivate pRb, this can lead to cancer. Retinoblastoma (RB) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral.

分子量

106159

NCBI登录号

NP_000312

UniProt

P06400

途径

Cell Division Cycle, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagy