ATM 抗体 (Ser1981)
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Quick Overview for ATM 抗体 (Ser1981) (ABIN319313)
抗原
See all ATM 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Ser1981
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特异性
- ATM Antibody AP08052PU detects endogenous levels of total ATM protein.
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纯化方法
- Immunoaffinity Chromatography using epitope-specific immunogen..
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免疫原
- The antiserum was produced against synthesized non-phosphopeptide derived from human ATM around the phosphorylation site of Serine 1981 (E-G-SP-Q-S).
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应用备注
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Western Blot: 1/500-1/1000. Immunofluorescence: 1/100-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the antibody (in aliquots) at-20 °C.
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- ATM (Ataxia Telangiectasia Mutated (ATM))
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别名
- ATM
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背景
- ATM is a 370 kDa nuclear phosphoprotein involved in the autosomal recessive disease Ataxia Telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation, apoptosis, and response to DNA damage repair (DNA damage caused by such things as ionizing irradiation activates ATM kinase). The C terminal region has extensive homology to the catalytic domains of Phosphatidylinositol 3 kinases (PI3 kinases).Synonyms: A-T mutated, ATDC, Ataxia telangiectasia mutated, Serine-protein kinase ATM, TEL1, TELO1
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基因ID
- 472
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NCBI登录号
- NP_000042
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UniProt
- Q13315
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途径
- p53 Pathway, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
抗原
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