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ATM 抗体 (Ser1981)

The 兔 多克隆 anti-ATM antibody is suitable to detect ATM in samples from 人 和 小鼠. It has been validated for WB 和 IF.
产品编号 ABIN319313
发货至: 中国
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Quick Overview for ATM 抗体 (Ser1981) (ABIN319313)

抗原

See all ATM 抗体
ATM (Ataxia Telangiectasia Mutated (ATM))

适用

  • 186
  • 78
  • 34
  • 3
  • 1
  • 1
人, 小鼠

宿主

  • 160
  • 20
  • 5
  • 2

克隆类型

  • 121
  • 66
多克隆

标记

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  • 11
  • 6
  • 6
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  • 3
  • 3
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  • 2
This ATM antibody is un-conjugated

应用范围

  • 111
  • 66
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  • 52
  • 50
  • 46
  • 41
  • 39
  • 28
  • 26
  • 8
  • 7
  • 4
  • 3
  • 2
  • 2
  • 1
Western Blotting (WB), Immunofluorescence (IF)
  • 抗原表位

    • 43
    • 16
    • 15
    • 13
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 5
    • 3
    • 2
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    • 1
    • 1
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    • 1
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    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Ser1981

    特异性

    ATM Antibody AP08052PU detects endogenous levels of total ATM protein.

    纯化方法

    Immunoaffinity Chromatography using epitope-specific immunogen..

    免疫原

    The antiserum was produced against synthesized non-phosphopeptide derived from human ATM around the phosphorylation site of Serine 1981 (E-G-SP-Q-S).
  • 应用备注

    Western Blot: 1/500-1/1000. Immunofluorescence: 1/100-1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C

    储存方法

    Store the antibody (in aliquots) at-20 °C.
  • 抗原

    ATM (Ataxia Telangiectasia Mutated (ATM))

    别名

    ATM

    背景

    ATM is a 370 kDa nuclear phosphoprotein involved in the autosomal recessive disease Ataxia Telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation, apoptosis, and response to DNA damage repair (DNA damage caused by such things as ionizing irradiation activates ATM kinase). The C terminal region has extensive homology to the catalytic domains of Phosphatidylinositol 3 kinases (PI3 kinases).Synonyms: A-T mutated, ATDC, Ataxia telangiectasia mutated, Serine-protein kinase ATM, TEL1, TELO1

    基因ID

    472

    NCBI登录号

    NP_000042

    UniProt

    Q13315

    途径

    p53 Pathway, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
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