SCNN1D 抗体
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- 抗原 See all SCNN1D 抗体
- SCNN1D (Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SCNN1D antibody is un-conjugated
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应用范围
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- 特异性
- This antibody detects endogenous levels of ENaCδ protein. (region surrounding Pro446)
- 交叉反应 （详细）
- Species reactivity (tested):Human.
- 纯化方法
- Affinity chromatography
- Top Product
- Discover our top product SCNN1D Primary Antibody
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anti-Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D) (C-Term) antibody
SCNN1D 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D) antibodySCNN1D 适用: 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D) (AA 292-519) antibodySCNN1D 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D) (AA 1-638) antibodySCNN1D 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D) (C-Term) antibodyVerified SCNN1D 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D) antibodySCNN1D 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D) (AA 411-460) antibodySCNN1D 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1,0 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- SCNN1D (Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D))
- 别名
- ENAC delta / SCNN1D (SCNN1D 产品)
- 别名
- Scnn1d antibody, SCNN1D antibody, ENaCd antibody, ENaCdelta antibody, SCNED antibody, dNaCh antibody, sodium channel, nonvoltage-gated 1, delta antibody, sodium channel epithelial 1 delta subunit antibody, Gm20552 antibody, SCNN1D antibody
- 背景
- The epithelial sodium channel (ENaC) is a member of the ENaC/DEG superfamily that is located on the apical surface of cells. ENaC mediates sodium reabsorption in kidney, distal colon, lung, ducts of exocrine glands and other organs. ENaC is formed by heteromultimerization of four homologous subunits, α, β, γ and δ. The most frequently formed heterotetramer consists of 2α, 1β, and 1γ subunit, but the α subunit can be replaced by a δ subunit. The αENaC gene maps to human chromosome 12p13, and expresses a glycosylated protein. Both the β and γENaC genes map to human chromosome 16p12, and the γENaC transcript is detected as a glycosylated protein. The carboxy-terminus of all ENaC subunits contains PY motifs, which interact with the ubiquitin protein ligase, Nedd4, to regulate intracellular sodium concentrations. Gain-of-function mutations involving the PY motif cause Liddle's syndrome, an autosomal dominant form of hypertension, resulting from excessive renal sodium absorption. Conversely, ENaC loss-of-function mutations result in pseudohypoaldosteronism type I, a disorder characterized by salt wasting and hypotension.Synonyms: Amiloride-sensitive sodium channel subunit delta, DNACH, Delta-ENaC, Delta-NaCH, ENaCD, Epithelial Na(+) channel subunit delta, Nonvoltage-gated sodium channel 1 subunit delta, SCNED
- 分子量
- approx. 80 kDa
- 基因ID
- 6339
- NCBI登录号
- NP_001123885
- UniProt
- P51172
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