CYP7B1 抗体
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- 抗原 See all CYP7B1 抗体
- CYP7B1 (Cytochrome P450, Family 7, Subfamily B, Polypeptide 1 (CYP7B1))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CYP7B1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- This antibody detects endogenous levels of CYP7B1 protein.(region surrounding Gln127)
- 纯化方法
- Affinity-Chromatography using epitope-specific immunogen
- Top Product
- Discover our top product CYP7B1 Primary Antibody
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anti-Cytochrome P450, Family 7, Subfamily B, Polypeptide 1 (CYP7B1) (AA 203-286) antibody
CYP7B1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2B11 unconjugated
anti-Cytochrome P450, Family 7, Subfamily B, Polypeptide 1 (CYP7B1) (AA 203-286) antibodyCYP7B1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Cytochrome P450, Family 7, Subfamily B, Polypeptide 1 (CYP7B1) (C-Term) antibodyCYP7B1 适用: 人 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 7, Subfamily B, Polypeptide 1 (CYP7B1) (AA 252-281) antibodyCYP7B1 适用: 人 WB, IHC (p), IF, FACS 宿主: 兔 Polyclonal RB17087 unconjugated
anti-Cytochrome P450, Family 7, Subfamily B, Polypeptide 1 (CYP7B1) antibodyCYP7B1 适用: 人 WB, IHC, FACS, IF/ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 7, Subfamily B, Polypeptide 1 (CYP7B1) (AA 312-430) antibodyCYP7B1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 7, Subfamily B, Polypeptide 1 (CYP7B1) (AA 1-506) antibodyCYP7B1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Cytochrome P450, Family 7, Subfamily B, Polypeptide 1 (CYP7B1) (C-Term) antibodyVerified CYP7B1 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Cytochrome P450, Family 7, Subfamily B, Polypeptide 1 (CYP7B1) (AA 304-353) antibodyCYP7B1 适用: 人, Pig, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 7, Subfamily B, Polypeptide 1 (CYP7B1) (AA 200-300) antibodyCYP7B1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- PBS pH ~7.2 with 0.05 % Sodium Azide as preservative
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- CYP7B1 (Cytochrome P450, Family 7, Subfamily B, Polypeptide 1 (CYP7B1))
- 别名
- CYP7B1 (CYP7B1 产品)
- 别名
- CYP7B1 antibody, CBAS3 antibody, CP7B antibody, SPG5A antibody, AW261589 antibody, D3Ertd552e antibody, hct-1 antibody, cytochrome P450 family 7 subfamily B member 1 antibody, cytochrome P450, family 7, subfamily B, polypeptide 1 antibody, cytochrome P450, family 7, subfamily b, polypeptide 1 antibody, CYP7B1 antibody, cyp7b1 antibody, Cyp7b1 antibody
- 背景
- P450 enzymes constitute a family of monooxygenase enzymes that are involved in the metabolism of a wide array of endogenous and xenobiotic compounds including cholesterol. CYP8B1 moderates the ratio of cholic acid over chenodeoxycholic acid to control the solubility of cholesterol. P450 cholesterol 7-hydroxylase, CYP7A1, is the rate limiting enzyme of bile acid synthesis in the liver, and its expression is mediated by the bile acid receptor FXR. CYP27A1 catalyzes vitamin D3 25-hydroxylation and is localized to the mitochondria in kidney and liver. CYP7B1 (oxysterol 7-α-hydroxylase) functions as an enzyme in the alternate bile acid synthesis pathway. Specifically, CYP7B1 metabolizes 25-and 27-hydroxycholesterol. The gene encoding human CYP7B1 maps to chromosome 8q21.3. Mutations in the CYP7B1 gene may cause a metabolic defect in bile acid synthesis characterized by elevated urinary bile acid excretion, severe cholestasis, cirrhosis and liver synthetic failure.Synonyms: 25-hydroxycholesterol 7-alpha-hydroxylase, Cytochrome P450 7B1, Oxysterol 7-alpha-hydroxylase
- 分子量
- approx. 58 kDa
- 基因ID
- 9420
- NCBI登录号
- NP_004811
- UniProt
- O75881
- 途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Biosynthesis, Regulation of Intracellular Steroid Hormone Receptor Signaling
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